APOBEC: A molecular driver in cervical cancer pathogenesis

S Revathidevi, AK Murugan, H Nakaoka, I Inoue… - Cancer letters, 2021 - Elsevier
Cervical cancer is one of the foremost common cancers in women. Human papillomavirus
(HPV) infection remains a major risk factor of cervical cancer. In addition, numerous other …

Interplay between inflammation and cancer

R Khandia, A Munjal - Advances in protein chemistry and structural biology, 2020 - Elsevier
During the 19th century, for the first time, the linkage between inflammation and cancer was
established. Inflammatory microenvironment is an essential component of the tumor …

[HTML][HTML] Lack of an association or an inverse association between low-density-lipoprotein cholesterol and mortality in the elderly: a systematic review

U Ravnskov, DM Diamond, R Hama, T Hamazaki… - BMJ open, 2016 - bmjopen.bmj.com
Objective It is well known that total cholesterol becomes less of a risk factor or not at all for all-
cause and cardiovascular (CV) mortality with increasing age, but as little is known as to …

Reactive oxygen species bridge the gap between chronic inflammation and tumor development

W Yu, Y Tu, Z Long, J Liu, D Kong… - Oxidative medicine …, 2022 - Wiley Online Library
According to numerous animal studies, adverse environmental stimuli, including physical,
chemical, and biological factors, can cause low‐grade chronic inflammation and subsequent …

[HTML][HTML] Association of oral dysbiosis with oral cancer development

GRM La Rosa, G Gattuso, E Pedullà… - Oncology …, 2020 - spandidos-publications.com
Oral squamous cell carcinoma (OSCC) is the leading cause of mortality for oral cancer.
Numerous risk factors mainly related to unhealthy habits and responsible for chronic …

[HTML][HTML] DNMT3b/OCT4 expression confers sorafenib resistance and poor prognosis of hepatocellular carcinoma through IL-6/STAT3 regulation

SC Lai, YT Su, CC Chi, YC Kuo, KF Lee, YC Wu… - Journal of Experimental …, 2019 - Springer
Background The inflammatory cytokine interleukin-6 (IL-6) is critical for the expression of
octamer-binding transcription factor 4 (OCT4), which is highly associated with early tumor …

[HTML][HTML] Alterations in oral bacterial communities are associated with risk factors for oral and oropharyngeal cancer

D Börnigen, B Ren, R Pickard, J Li, E Ozer… - Scientific reports, 2017 - nature.com
Oral squamous cell carcinomas are a major cause of morbidity and mortality, and tobacco
usage, alcohol consumption, and poor oral hygiene are established risk factors. To date, no …

Association of human papillomavirus infection and inflammation in cervical cancer

N Hemmat, H Bannazadeh Baghi - Pathogens and disease, 2019 - academic.oup.com
Human papillomavirus (HPV) associated cancers, and in particular cervical cancer, are
considered to be directly stimulated by HPV oncogenes. Alternatively, these types of cancers …

Functions and malfunctions of mammalian DNA-cytosine deaminases

SU Siriwardena, K Chen, AS Bhagwat - Chemical reviews, 2016 - ACS Publications
The AID/APOBEC family enzymes convert cytosines in single-stranded DNA to uracils,
causing base substitutions and strand breaks. They are induced by cytokines produced …

[HTML][HTML] Association between low density lipoprotein cholesterol and all-cause mortality: results from the NHANES 1999–2014

Y Liu, F Liu, L Zhang, J Li, W Kang, M Cao, F Song… - Scientific reports, 2021 - nature.com
The association between low density lipoprotein cholesterol (LDL-C) and all-cause mortality
has been examined in many studies. However, inconsistent results and limitations still exist …