The molecular basis for cellular function of intrinsically disordered protein regions
AS Holehouse, BB Kragelund - Nature Reviews Molecular Cell Biology, 2024 - nature.com
Intrinsically disordered protein regions exist in a collection of dynamic interconverting
conformations that lack a stable 3D structure. These regions are structurally heterogeneous …
conformations that lack a stable 3D structure. These regions are structurally heterogeneous …
Transcription factor dynamics: one molecule at a time
K Wagh, DA Stavreva, A Upadhyaya… - Annual Review of Cell …, 2023 - annualreviews.org
Cells must tightly regulate their gene expression programs and yet rapidly respond to acute
biochemical and biophysical cues within their environment. This information is transmitted to …
biochemical and biophysical cues within their environment. This information is transmitted to …
Multifunctional intrinsically disordered regions in transcription factors
M Már, K Nitsenko… - Chemistry–A European …, 2023 - Wiley Online Library
Eukaryotic transcription factors (TFs) are the final integrators of a complex molecular
feedback mechanism that interfaces with the genome, consolidating information for …
feedback mechanism that interfaces with the genome, consolidating information for …
Complementary strategies for directing in vivo transcription factor binding through DNA binding domains and intrinsically disordered regions
DNA binding domains (DBDs) of transcription factors (TFs) recognize DNA sequence motifs
that are highly abundant in genomes. Within cells, TFs bind a subset of motif-containing sites …
that are highly abundant in genomes. Within cells, TFs bind a subset of motif-containing sites …
The molecular grammar of protein disorder guiding genome-binding locations
F Jonas, M Carmi, B Krupkin, J Steinberger… - Nucleic acids …, 2023 - academic.oup.com
Intrinsically disordered regions (IDRs) direct transcription factors (TFs) towards selected
genomic occurrences of their binding motif, as exemplified by budding yeast's Msn2 …
genomic occurrences of their binding motif, as exemplified by budding yeast's Msn2 …
Evolution of binding preferences among whole-genome duplicated transcription factors
Throughout evolution, new transcription factors (TFs) emerge by gene duplication,
promoting growth and rewiring of transcriptional networks. How TF duplicates diverge was …
promoting growth and rewiring of transcriptional networks. How TF duplicates diverge was …
Revisiting the model for coactivator recruitment: Med15 can select its target sites independent of promoter-bound transcription factors
Activation domains (ADs) within transcription factors (TFs) induce gene expression by
recruiting coactivators such as the Mediator complex. Coactivators lack DNA binding …
recruiting coactivators such as the Mediator complex. Coactivators lack DNA binding …
Transcription factors perform a 2-step search of the nucleus
MV Staller - Genetics, 2022 - academic.oup.com
Transcription factors regulate gene expression by binding to regulatory DNA and recruiting
regulatory protein complexes. The DNA-binding and protein-binding functions of …
regulatory protein complexes. The DNA-binding and protein-binding functions of …
Connecting sequence features within the disordered C-terminal linker of Bacillus subtilis FtsZ to functions and bacterial cell division
Intrinsically disordered regions (IDRs) can function as autoregulators of folded enzymes to
which they are tethered. One example is the bacterial cell division protein FtsZ. This includes …
which they are tethered. One example is the bacterial cell division protein FtsZ. This includes …
The architecture of binding cooperativity between densely bound transcription factors
The binding of transcription factors (TFs) along genomes is restricted to a subset of sites
containing their preferred motifs. TF-binding specificity is often attributed to the co-binding of …
containing their preferred motifs. TF-binding specificity is often attributed to the co-binding of …