Biomedical research is undergoing a paradigm shift towards approaches centred on human
disease models owing to the notoriously high failure rates of the current drug development …

Retinal development and maturation are orchestrated by a series of interacting signalling
networks that drive the morphogenetic transformation of the anterior developing brain …

Inherited retinal diseases (IRDs) cause progressive loss of light-sensitive photoreceptors in
the eye and can lead to blindness. Gene-based therapies for IRDs have shown remarkable …

Background Induced pluripotent stem cells (iPSCs) offer potential to revolutionize
regenerative medicine as a renewable source for islets, dopaminergic neurons, retinal cells …

Abstract Inherited Retinal Diseases (IRDs) are considered one of the leading causes of
blindness worldwide. However, the majority of them still lack a safe and effective treatment …

Retinal diseases are a rising concern as major causes of blindness in an aging society;
therapeutic options are limited, and the precise pathogenesis of these diseases remains …

Human organoids stand at the forefront of basic and translational research, providing
experimentally tractable systems to study human development and disease. These stem cell …

Purpose: To expand the use of human retinal organoids from induced pluripotent stem cells
(iPSCs) as an in vitro model of the retina for assessing gene therapy treatments, it is …

Despite the progress of modern medicine in the last decades, millions of people diagnosed
with retinal dystrophies (RDs), such as retinitis pigmentosa, or age-related diseases, such as …

Purpose Retinal organoids (ROs) derived from human pluripotent stem cells largely
recapitulate key features of in vivo retinal development, thus permitting the study of …