As the ubiquitin–proteasome system (UPS) regulates almost every biological process, the
dysregulation or aberrant expression of the UPS components causes many pathological …

In the 20 years since the first report of a proteolysis targeting chimeric (PROTAC) molecule,
targeted protein degradation (TPD) technologies have attempted to revolutionize the fields …

Polyglutamine (polyQ) diseases are a group of inherited neurodegenerative disorders
caused by expanded cytosine-adenine-guanine (CAG) repeats encoding proteins with …

Macroautophagy/autophagy plays an important role in regulating cellular homeostasis and
influences the pathogenesis of degenerative diseases. Tendinopathy is characterized by …

Deubiquitinating enzymes are key regulators in the ubiquitin system and an emerging class
of drug targets. These proteases disassemble polyubiquitin chains and many …

The intricate molecular landscape of cancer pathogenesis continues to captivate
researchers worldwide, with Circular RNAs (circRNAs) emerging as pivotal players in the …

Triple-negative breast cancer (TNBC) is a heterogeneous malignancy in women. It is
associated with poor prognosis, aggressive malignant behavior, and limited treatment …

The retinoblastoma protein (pRb) functions as a cell cycle regulator controlling G1 to S
phase transition and plays critical roles in tumour suppression. It is frequently inactivated in …

Objective Osteoarthritis (OA) is one of the most common degenerative joint diseases and is
associated with autophagy suppression. However, the molecular mechanism of autophagy …

Summary Modular SCF (SKP1-CUL1-Fbox) ubiquitin E3 ligases orchestrate multiple cellular
pathways in eukaryotes. Their variable SKP1-Fbox substrate receptor (SR) modules enable …