Tau is a microtubule-associated protein that has a role in stabilizing neuronal microtubules
and thus in promoting axonal outgrowth. Structurally, tau is a natively unfolded protein, is …

General anaesthesia is usually considered to safely induce a reversible brain state allowing
the performance of surgery under optimal conditions. An increasing number of clinical and …

The microtubule-associated protein tau has been implicated in the pathogenesis of
Alzheimer's disease (AD) and other neurodegenerative disorders. Reducing tau levels …

Emerging experimental evidence suggests that the spread of tau pathology in the brain in
Tauopathies reflects the propagation of abnormal tau species along neuroanatomically …

Background The impact of general anesthesia on cognitive impairment is controversial and
complex. A large body of evidence supports the association between exposure to surgery …

Background: Previous clinical trials and animal experiments have suggested that long-
lasting neurotoxicity of general anesthetics may lead to postoperative cognitive dysfunction …

Tau represents the subunit protein of one of the major hallmarks of Alzheimer disease (AD),
the neurofibrillary tangles, and is therefore of major interest as an indicator of disease …

Tau is the major microtubule associated protein (MAP) of a mature neuron. The other two
neuronal MAPs are MAP1 and MAP2. An established function of MAPs is their interaction …

The mechanisms underpinning concussion, traumatic brain injury, and chronic traumatic
encephalopathy, and the relationships between these disorders, are poorly understood. We …

Tau is a microtubule-associated-protein that is sorted into neuronal axons in physiological
conditions. In Alzheimer disease (AD) and other tauopathies, Tau sorting mechanisms fail …