New insights into activation and function of the AMPK
GR Steinberg, DG Hardie - Nature reviews Molecular cell biology, 2023 - nature.com
The classical role of AMP-activated protein kinase (AMPK) is as a cellular energy sensor
activated by falling energy status, signalled by increases in AMP to ATP and ADP to ATP …
activated by falling energy status, signalled by increases in AMP to ATP and ADP to ATP …
Cellular and molecular mechanisms of metformin action
TE LaMoia, GI Shulman - Endocrine reviews, 2021 - academic.oup.com
Metformin is a first-line therapy for the treatment of type 2 diabetes, due to its robust glucose-
lowering effects, well-established safety profile, and relatively low cost. While metformin has …
lowering effects, well-established safety profile, and relatively low cost. While metformin has …
The MAPK and AMPK signalings: interplay and implication in targeted cancer therapy
J Yuan, X Dong, J Yap, J Hu - Journal of hematology & oncology, 2020 - Springer
Cancer is characterized as a complex disease caused by coordinated alterations of multiple
signaling pathways. The Ras/RAF/MEK/ERK (MAPK) signaling is one of the best-defined …
signaling pathways. The Ras/RAF/MEK/ERK (MAPK) signaling is one of the best-defined …
AMPK and the adaptation to exercise
HR Spaulding, Z Yan - Annual review of physiology, 2022 - annualreviews.org
Noncommunicable diseases are chronic diseases that contribute to death worldwide, but
these diseases can be prevented and mitigated with regular exercise. Exercise activates …
these diseases can be prevented and mitigated with regular exercise. Exercise activates …
AMPK: an energy-sensing pathway with multiple inputs and outputs
AMP-activated protein kinase (AMPK) is a key regulator of energy balance expressed
ubiquitously in eukaryotic cells. Here we review the canonical adenine nucleotide …
ubiquitously in eukaryotic cells. Here we review the canonical adenine nucleotide …
AMP-activated protein kinase: An energy sensor and survival mechanism in the reinstatement of metabolic homeostasis
Cells are programmed to favorably respond towards the nutrient availability by adapting
their metabolism to meet energy demands. AMP-activated protein kinase (AMPK) is a highly …
their metabolism to meet energy demands. AMP-activated protein kinase (AMPK) is a highly …
AMPK: a nutrient and energy sensor that maintains energy homeostasis
DG Hardie, FA Ross, SA Hawley - Nature reviews Molecular cell biology, 2012 - nature.com
AMP-activated protein kinase (AMPK) is a crucial cellular energy sensor. Once activated by
falling energy status, it promotes ATP production by increasing the activity or expression of …
falling energy status, it promotes ATP production by increasing the activity or expression of …
Mitochondria-localized AMPK responds to local energetics and contributes to exercise and energetic stress-induced mitophagy
Mitochondria form a complex, interconnected reticulum that is maintained through
coordination among biogenesis, dynamic fission, and fusion and mitophagy, which are …
coordination among biogenesis, dynamic fission, and fusion and mitophagy, which are …
AMPK: positive and negative regulation, and its role in whole-body energy homeostasis
DG Hardie - Current opinion in cell biology, 2015 - Elsevier
The AMP-activated protein kinase (AMPK) is a sensor of energy status that, when activated
by metabolic stress, maintains cellular energy homeostasis by switching on catabolic …
by metabolic stress, maintains cellular energy homeostasis by switching on catabolic …
AMP is a true physiological regulator of AMP-activated protein kinase by both allosteric activation and enhancing net phosphorylation
While allosteric activation of AMPK is triggered only by AMP, binding of both ADP and AMP
has been reported to promote phosphorylation and inhibit dephosphorylation at Thr172 …
has been reported to promote phosphorylation and inhibit dephosphorylation at Thr172 …