Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host
response to infection. It remains a highly lethal condition in which current tools for early …

There is no standard definition for trauma-induced coagulopathy (TIC). However, it could be
defined as an abnormal hemostatic response secondary to trauma. The terms “early TIC” …

Understanding the pharmacokinetics, blood compatibility, biodistribution and clearance
properties of nanoparticles is of great importance to their translation to clinical application. In …

Background The advances of research on extracellular vesicles (EVs) are of particular
interest to the clinicians as well as the researchers who are studying coagulation disorder in …

Anticoagulant drugs (ie, unfractionated heparin, low-molecular-weight heparins, vitamin K
antagonists, and direct oral anticoagulants) are widely employed in preventing and treating …

Tissue factor (TF) is the primary trigger of coagulation. Elevated levels of TF are found in
atherosclerotic plaques and TF leads to thrombus formation when released upon plaque …

Orthotopic liver transplantation (OLT) remains a potentially hemorrhagic procedure.
Rotational thromboelastometry (ROTEM) is a point‐of‐care device used to monitor …

With the advent of new viscoelastometric hemostatic assay (VHA) devices, with ready-to-use
cartridge reagents allowing for their use by people without special laboratory skills, the …

Several hemostatic strategies rely on the use of blood components such as fibrinogen and
thrombin, which suffer from high cost and short shelf‐life. Here, a cost‐effective synthetic …

The non-activated thromboelastometry (NATEM) assay is a point-of-care assay that can
provide a comprehensive insight into the actual hemostatic mechanism. However, there are …