Chronic unpredictable mild stress for modeling depression in rodents: Meta-analysis of model reliability
S Antoniuk, M Bijata, E Ponimaskin… - … & Biobehavioral Reviews, 2019 - Elsevier
Depression is currently among the top five leading causes of the global burden of disease.
Chronic unpredictable mild stress (CUMS) is currently the most commonly used, reliable …
Chronic unpredictable mild stress (CUMS) is currently the most commonly used, reliable …
On inflammatory hypothesis of depression: what is the role of IL-6 in the middle of the chaos?
E Roohi, N Jaafari, F Hashemian - Journal of neuroinflammation, 2021 - Springer
Many patients with major depressive disorder (MDD) are reported to have higher levels of
multiple inflammatory cytokines including interleukin 6 (IL-6). Recent studies both pre …
multiple inflammatory cytokines including interleukin 6 (IL-6). Recent studies both pre …
Therapeutic endocannabinoid augmentation for mood and anxiety disorders: comparative profiling of FAAH, MAGL and dual inhibitors
Recent studies have demonstrated anxiolytic potential of pharmacological endocannabinoid
(eCB) augmentation approaches in a variety of preclinical models. Pharmacological …
(eCB) augmentation approaches in a variety of preclinical models. Pharmacological …
Leptin in depression: a potential therapeutic target
T Ge, J Fan, W Yang, R Cui, B Li - Cell Death & Disease, 2018 - nature.com
Leptin, produced and secreted by white adipose tissue, plays a critical role in regulating
body weight, food intake, and energy metabolism. Recently, several studies have identified …
body weight, food intake, and energy metabolism. Recently, several studies have identified …
[HTML][HTML] Finding intestinal fortitude: Integrating the microbiome into a holistic view of depression mechanisms, treatment, and resilience
Depression affects at least 322 million people globally, or approximately 4.4% of the world's
population. While the earnestness of researchers and clinicians to understand and treat …
population. While the earnestness of researchers and clinicians to understand and treat …
Novel treatment options in depression and psychosis
E Ceskova, P Silhan - Neuropsychiatric disease and treatment, 2018 - Taylor & Francis
In spite of tremendous development in central nervous system research, current treatment is
suboptimal, especially in severe mental disorders. In medicine, there are two main methods …
suboptimal, especially in severe mental disorders. In medicine, there are two main methods …
The role of genetics in the development and pharmacotherapy of depression and its impact on drug discovery
Complex disorders, such as depression, remain a mystery for scientists. Although genetic
factors are considered important for the prediction of one's vulnerability, it is hard to estimate …
factors are considered important for the prediction of one's vulnerability, it is hard to estimate …
International union of basic and clinical pharmacology CIV: the neurobiology of treatment-resistant depression: from antidepressant classifications to novel …
Major depressive disorder is one of the most prevalent and life-threatening forms of mental
illnesses and a major cause of morbidity worldwide. Currently available antidepressants are …
illnesses and a major cause of morbidity worldwide. Currently available antidepressants are …
Is there a future for PPARs in the treatment of neuropsychiatric disorders?
Recently, peroxisome proliferator-activated receptor (PPAR)-α and γ isoforms have been
gaining consistent interest in neuropathology and treatment of neuropsychiatric disorders …
gaining consistent interest in neuropathology and treatment of neuropsychiatric disorders …
Rapid effects of S-ketamine on the morphology of hippocampal astrocytes and BDNF serum levels in a sex-dependent manner
The prevalence of major depressive disorder (MDD) is higher in women than men.
Importantly, a differential behavioral response by sex to the antidepressant response to …
Importantly, a differential behavioral response by sex to the antidepressant response to …