Subchondral bone remodeling: a therapeutic target for osteoarthritis
There is emerging awareness that subchondral bone remodeling plays an important role in
the development of osteoarthritis (OA). This review presents recent investigations on the …
the development of osteoarthritis (OA). This review presents recent investigations on the …
The benefits and limitations of animal models for translational research in cartilage repair
CJ Moran, A Ramesh, PAJ Brama, JM O'Byrne… - Journal of experimental …, 2016 - Springer
Much research is currently ongoing into new therapies for cartilage defect repair with new
biomaterials frequently appearing which purport to have significant regenerative capacity …
biomaterials frequently appearing which purport to have significant regenerative capacity …
Innovative tissue‐engineered strategies for osteochondral defect repair and regeneration: current progress and challenges
L Zhou, VO Gjvm, J Malda, MJ Stoddart… - Advanced …, 2020 - Wiley Online Library
Clinical treatments for the repair of osteochondral defects (OCD) are merely palliative, not
completely curative, and thus enormously unfulfilled challenges. With the in‐depth studies of …
completely curative, and thus enormously unfulfilled challenges. With the in‐depth studies of …
Bioactive factors for cartilage repair and regeneration: improving delivery, retention, and activity
Articular cartilage is a remarkable tissue whose sophisticated composition and architecture
allow it to withstand complex stresses within the joint. Once injured, cartilage lacks the …
allow it to withstand complex stresses within the joint. Once injured, cartilage lacks the …
[HTML][HTML] In vitro and in vivo investigation of a zonal microstructured scaffold for osteochondral defect repair
Articular cartilage is comprised of zones that vary in architecture, extracellular matrix
composition, and mechanical properties. Here, we designed and engineered a porous zonal …
composition, and mechanical properties. Here, we designed and engineered a porous zonal …
Allogeneic umbilical cord blood–derived mesenchymal stem cell implantation versus microfracture for large, full-thickness cartilage defects in older patients: A …
HC Lim, YB Park, CW Ha, BJ Cole… - … Journal of Sports …, 2021 - journals.sagepub.com
Background: There is currently no optimal method for cartilage restoration in large, full-
thickness cartilage defects in older patients. Purpose: To determine whether implantation of …
thickness cartilage defects in older patients. Purpose: To determine whether implantation of …
Navigating regulatory pathways for translation of biologic cartilage repair products
Long-term clinical repair of articular cartilage remains elusive despite advances in cartilage
tissue engineering. Only one cartilage repair therapy classified as a “cellular and gene …
tissue engineering. Only one cartilage repair therapy classified as a “cellular and gene …
Catechol-functionalized hyaluronic acid hydrogels enhance angiogenesis and osteogenesis of human adipose-derived stem cells in critical tissue defects
Over the last few decades, stem cell therapies have been highlighted for their potential to
heal damaged tissue and aid in tissue reconstruction. However, materials used to deliver …
heal damaged tissue and aid in tissue reconstruction. However, materials used to deliver …
A bioactive supramolecular and covalent polymer scaffold for cartilage repair in a sheep model
Regeneration of hyaline cartilage in human-sized joints remains a clinical challenge, and it
is a critical unmet need that would contribute to longer healthspans. Injectable scaffolds for …
is a critical unmet need that would contribute to longer healthspans. Injectable scaffolds for …
Animal models of osteochondral defect for testing biomaterials
The treatment of osteochondral defects (OCD) remains a great challenge in orthopaedics.
Tissue engineering holds a good promise for regeneration of OCD. In the light of tissue …
Tissue engineering holds a good promise for regeneration of OCD. In the light of tissue …