Research on astronaut health and model organisms have revealed six features of
spaceflight biology that guide our current understanding of fundamental molecular changes …

Bone turnover comprises two processes: the removal of old bone (resorption) and the laying
down of new bone (formation). N-terminal propeptide of type I procollagen (PINP) and C …

INTRODUCTION To date, 559 humans have been flown into space, but long-duration (> 300
days) missions are rare (n= 8 total). Long-duration missions that will take humans to Mars …

Spaceflight is known to impose changes on human physiology with unknown molecular
etiologies. To reveal these causes, we used a multi-omics, systems biology analytical …

With the reignited push for manned spaceflight and the development of companies focused
on commercializing spaceflight, increased human ventures into space are inevitable …

Bone loss in space travelers is a major challenge for long-duration space exploration. To
quantify microgravity-induced bone loss in humans, we performed a meta-analysis of …

Experiencing real weightlessness in space is a dream for many of us who are interested in
space research. Although space traveling fascinates us, it can cause both short-term and …

Abstract Space sojourns are challenging for life. The ability of the human body to adapt to
these extreme conditions has been noted since the beginning of human space travel …

Abstract The SpaceX Inspiration4 mission provided a unique opportunity to study the impact
of spaceflight on the human body. Biospecimen samples were collected from four crew …

The rodent hindlimb unloading (HU) model was developed in the 1980s to make it possible
to study mechanisms, responses, and treatments for the adverse consequences of …