Hypoxia is a state of low oxygen tension found in numerous solid tumours. It is typically
associated with abnormal vasculature, which results in a reduced supply of oxygen and …

This review provides an overview of metal-based anticancer drugs and drug candidates. In
particular, we focus on metal complexes that can be activated in the reducing environment of …

Twenty-nine new 6 (7)-substituted quinoxaline-2-carboxylate 1, 4-dioxide derivatives were
synthesized and evaluated for in vitro antituberculosis activity. In general, the in vitro activity …

Anticancer prodrugs designed to target specifically tumor cells should increase therapeutic
effectiveness and decrease systemic side effects in the treatment of cancer. Over the last 20 …

We report the synthesis, anti-inflammatory and antioxidant activities of novel ring substituted
3-phenyl-1-(1, 4-di-N-oxide quinoxalin-2-yl)-2-propen-1-one derivatives and of their 4, 5 …

Covering: 2000 to 2011 Phenazines are a large group of natural and synthesised nitrogen-
containing heterocycles, including more than 100 different compounds of natural origin and …

Thirty-six 6 (7)-substituted-3-methyl-or 3-halogenomethyl-2-phenylthio–phenylsulphonyl–
chloro-quinoxaline 1, 4-dioxides belonging to series 3–6 were synthesised and submitted to …

Quinoxaline 1, 4-di-N-oxides (QdNOs) have manifold biological properties, including
antimicrobial, antitumoral, antitrypanosomal and antiinflammatory/antioxidant activities …

Hypoxia is a feature of some regions of many tumours, ischaemic events, and arthritis. Drugs
activated in hypoxia have wide potential application, particularly in overcoming the …

There is evidence that hypoxic cells exist in both animal and human tumorsand that oxygen-
deficient malignant cells are significantly more resistant to ionizing radiation than their …