Chronic kidney disease: strategies to retard progression

MT Yan, CT Chao, SH Lin - International journal of molecular sciences, 2021 - mdpi.com
Chronic kidney disease (CKD), defined as the presence of irreversible structural or
functional kidney damages, increases the risk of poor outcomes due to its association with …

Protecting the kidney in systemic lupus erythematosus: from diagnosis to therapy

NI Maria, A Davidson - Nature Reviews Rheumatology, 2020 - nature.com
Lupus nephritis (LN) is a common manifestation of systemic lupus erythematosus that can
lead to irreversible renal impairment. Although the prognosis of LN has improved …

A single genetic locus controls both expression of DPEP1/CHMP1A and kidney disease development via ferroptosis

Y Guan, X Liang, Z Ma, H Hu, H Liu, Z Miao… - Nature …, 2021 - nature.com
Genome-wide association studies (GWAS) have identified loci for kidney disease, but the
causal variants, genes, and pathways remain unknown. Here we identify two kidney disease …

Association between periodontitis and chronic kidney disease

K Parsegian, D Randall, M Curtis… - Periodontology …, 2022 - Wiley Online Library
Periodontitis and chronic kidney disease are chronic conditions with high community
prevalence across the world. Patients with chronic kidney disease have been noted to have …

Gender differences in diabetic kidney disease: focus on hormonal, genetic and clinical factors

A Giandalia, AE Giuffrida, G Gembillo… - International journal of …, 2021 - mdpi.com
Diabetic kidney disease (DKD) is one of the most serious complications of both type 1
(T1DM) and type 2 diabetes mellitus (T2DM). Current guidelines recommend a personalized …

The role of mitochondrial mutations and chronic inflammation in diabetes

SA Dabravolski, VA Orekhova, MS Baig… - International journal of …, 2021 - mdpi.com
Diabetes mellitus and related disorders significantly contribute to morbidity and mortality
worldwide. Despite the advances in the current therapeutic methods, further development of …

Polygenic risk alters the penetrance of monogenic kidney disease

A Khan, N Shang, JG Nestor, C Weng… - Nature …, 2023 - nature.com
Chronic kidney disease (CKD) is determined by an interplay of monogenic, polygenic, and
environmental risks. Autosomal dominant polycystic kidney disease (ADPKD) and COL4A …

[HTML][HTML] Role of mitochondrial DNA in diabetes Mellitus Type I and Type II

BA Al-Ghamdi, JM Al-Shamrani, AM El-Shehawi… - Saudi Journal of …, 2022 - Elsevier
Morbidity and mortality from diabetes mellitus and associated illnesses is a major problem
across the globe. Anti-diabetic medicines must be improved despite existing breakthroughs …

[HTML][HTML] The use of 'omics for diagnosing and predicting progression of chronic kidney disease: A scoping review

MA Govender, JT Brandenburg, J Fabian… - Frontiers in …, 2021 - frontiersin.org
Globally, chronic kidney disease (CKD) contributes substantial morbidity and mortality.
Recently, various 'omics platforms have provided insight into the molecular basis of kidney …

[HTML][HTML] Mechanisms of ferroptosis in chronic kidney disease

WQ Zhuo, Y Wen, HJ Luo, ZL Luo… - Frontiers in Molecular …, 2022 - frontiersin.org
Ferroptosis is a newly identified form of regulated cell death characterized by iron
accumulation and lipid peroxidation. Ferroptosis plays an essential role in the pathology of …