Current anti-diabetic agents and their molecular targets: A review

N Kerru, A Singh-Pillay, P Awolade, P Singh - European Journal of …, 2018 - Elsevier
Diabetes mellitus is a medical condition characterized by the body's loss of control over
blood sugar. The frequency of diagnosed cases and consequential increases in medical …

Pyrrole: An emerging scaffold for construction of valuable therapeutic agents

SS Gholap - European journal of medicinal chemistry, 2016 - Elsevier
Pyrrole derivatives comprise a class of biologically active heterocyclic compounds which
can serve as promising scaffolds for antimicrobial, antiviral, antimalarial, antitubercular, anti …

Anti-diabetic drugs recent approaches and advancements

J Dowarah, VP Singh - Bioorganic & medicinal chemistry, 2020 - Elsevier
Diabetes is one of the major diseases worldwide and is the third leading cause of death in
the United States. Anti-diabetic drugs are used in the treatment of diabetes mellitus to control …

Updates on aldose reductase inhibitors for management of diabetic complications and non-diabetic diseases

A Singh Grewal, S Bhardwaj, D Pandita… - Mini reviews in …, 2016 - ingentaconnect.com
Diabetes mellitus occurrence has been associated to the modification of the physiological
levels of glucose and is often accompanied by several long-term complications, namely …

Targeting aldose reductase for the treatment of diabetes complications and inflammatory diseases: new insights and future directions

R Maccari, R Ottanà - Journal of medicinal chemistry, 2015 - ACS Publications
Aldose reductase (AR) is an aldo–keto reductase that has been widely investigated as an
enzyme crucially involved in the pathogenesis of chronic complications associated with …

Aldose reductase and protein tyrosine phosphatase 1B inhibitors as a promising therapeutic approach for diabetes mellitus

A Kousaxidis, A Petrou, V Lavrentaki… - European Journal of …, 2020 - Elsevier
Diabetes mellitus is a metabolic disease characterized by high blood glucose levels and
usually associated with several chronic pathologies. Aldose reductase and protein tyrosine …

Pyrrole: A Decisive Scaffold for the Development of Therapeutic Agents and Structure‐Activity Relationship

BH Ganesh, AG Raj, B Aruchamy, P Nanjan… - …, 2024 - Wiley Online Library
An overview of pyrroles as distinct scaffolds with therapeutic potential and the significance of
pyrrole derivatives for drug development are provided in this article. It lists instances of …

Non-acidic bifunctional benzothiazole-based thiazolidinones with antimicrobial and aldose reductase inhibitory activity as a promising therapeutic strategy for sepsis

A Kousaxidis, L Kovacikova, I Nicolaou… - Medicinal Chemistry …, 2021 - Springer
Sepsis is a life-threatening disease that affects millions of people worldwide. Microbial
infections that lead to sepsis syndrome are associated with an increased production of …

[HTML][HTML] Orofacial antinociceptive effect of Mimosa tenuiflora (Willd.) Poiret

FEA Magalhaes, FLA Batista, OF Serpa… - Biomedicine & …, 2018 - Elsevier
Abstract Mimosa tenuiflora (Willd.) Poiret, popularly known in Brazil as “jurema-preta” is
widely used against bronchitis, fever, headache and inflammation. Its antioxidant, anti …

Ferrocenes as potential chemotherapeutic drugs: Synthesis, cytotoxic activity, reactive oxygen species production and micronucleus assay

WI Pérez, Y Soto, C Ortíz, J Matta… - Bioorganic & medicinal …, 2015 - Elsevier
Three new ferrocene complexes were synthesized with 4-(1 H-pyrrol-1-yl) phenol group
appended to one of the Cp ring. These are: 1, 1′-4-(1H-pyrrol-1-yl) phenyl …