Animal modeling for primary brain tumors has undergone constant development over the
last 60 years, and significant improvements have been made recently with the establishment …

Suicide gene therapy is based on the introduction into tumor cells of a viral or a bacterial
gene, which allows the conversion of a non-toxic compound into a lethal drug. Although …

The transfer of intact mitochondria between heterogeneous cell types has been confirmed in
various settings, including cancer. However, the functional implications of mitochondria …

Lentiviral vectors (LVs) have gained value over recent years as gene carriers in gene
therapy. These viral vectors are safer than what was previously being used for gene transfer …

Glioblastoma is the most common and lethal type of primary brain tumor. Despite recent
therapeutic advances in other cancers, the treatment of glioblastomas remains ineffective …

Glioblastoma (GBM) is the most common and aggressive primary brain tumor in the adult
population and it carries a dismal prognosis. Inefficient drug delivery across the blood brain …

Angiogenesis is regarded as a hallmark of cancer progression and it has been postulated
that solid tumor growth depends on angiogenesis. At present, however, it is clear that tumor …

Background Amplification of the epidermal growth factor receptor (EGFR) and its mutant
EGFRvIII are among the most common genetic alterations in glioblastoma (GBM), the most …

Glioblastoma (GBM) brain tumor remains among the most lethal and incurable human
diseases. Oncogenic microRNA-10b (miR-10b) is strongly and universally upregulated in …

The interest in lentiviral vectors (LVs) has increased prominently for gene therapy
applications, but few have reached the later stages of clinical trials. The main challenge has …