The Potential of Deep Learning to Advance Clinical Applications of Computational Biomechanics

GA Truskey - Bioengineering, 2023 - mdpi.com
When combined with patient information provided by advanced imaging techniques,
computational biomechanics can provide detailed patient-specific information about …

Examining metastatic behavior within 3D bioprinted vasculature for the validation of a 3D computational flow model

WF Hynes, M Pepona, C Robertson, J Alvarado… - Science …, 2020 - science.org
Understanding the dynamics of circulating tumor cell (CTC) behavior within the vasculature
has remained an elusive goal in cancer biology. To elucidate the contribution of …

Hemodynamic and morphological characteristics of a growing cerebral aneurysm

M Dabagh, P Nair, J Gounley, D Frakes… - Neurosurgical …, 2019 - thejns.org
The growth of cerebral aneurysms is linked to local hemodynamic conditions, but the driving
mechanisms of the growth are poorly understood. The goal of this study was to examine the …

Massively parallel models of the human circulatory system

A Randles, EW Draeger, T Oppelstrup… - Proceedings of the …, 2015 - dl.acm.org
The potential impact of blood flow simulations on the diagnosis and treatment of patients
suffering from vascular disease is tremendous. Empowering models of the full arterial tree …

Role of deformable cancer cells on wall shear stress-associated-VEGF secretion by endothelium in microvasculature

M Dabagh, A Randles - PloS one, 2019 - journals.plos.org
Endothelial surface layer (glycocalyx) is the major physiological regulator of tumor cell
adhesion to endothelium. Cancer cells express vascular endothelial growth factor (VEGF) …

Diagnostic performance of coronary angiography derived computational fractional flow reserve

M Vardhan, C Tanade, SJ Chen… - Journal of the …, 2024 - ahajournals.org
Background Computational fluid dynamics can compute fractional flow reserve (FFR)
accurately. However, existing models are limited by either the intravascular hemodynamic …

GPU data access on complex geometries for D3Q19 lattice Boltzmann method

G Herschlag, S Lee, JS Vetter… - 2018 IEEE International …, 2018 - ieeexplore.ieee.org
GPU performance of the lattice Boltzmann method (LBM) depends heavily on memory
access patterns. When LBM is advanced with GPUs on complex computational domains …

Localization of rolling and firm-adhesive interactions between circulating tumor cells and the microvasculature wall

M Dabagh, J Gounley, A Randles - Cellular and Molecular Bioengineering, 2020 - Springer
Introduction The adhesion of tumor cells to vessel wall is a critical stage in cancer
metastasis. Firm adhesion of cancer cells is usually followed by their extravasation through …

Numerical simulation of a compound capsule in a constricted microchannel

J Gounley, EW Draeger, A Randles - Procedia computer science, 2017 - Elsevier
Simulations of the passage of eukaryotic cells through a constricted channel aid in studying
the properties of cancer cells and their transport in the bloodstream. Compound capsules …

Uncertainty quantification of the impact of peripheral arterial disease on abdominal aortic aneurysms in blood flow simulations

SCY Lo, JWS McCullough, X Xue… - Journal of the Royal …, 2024 - royalsocietypublishing.org
Peripheral arterial disease (PAD) and abdominal aortic aneurysms (AAAs) often coexist and
pose significant risks of mortality, yet their mutual interactions remain largely unexplored …