Protein lipidation, including cysteine prenylation, N-terminal glycine myristoylation, cysteine
palmitoylation, and serine and lysine fatty acylation, occurs in many proteins in eukaryotic …

Protein S-acylation, the only fully reversible posttranslational lipid modification of proteins, is
emerging as a ubiquitous mechanism to control the properties and function of a diverse …

Bone-forming cells originate from distinct embryological layers, mesoderm (axial and
appendicular bones) and ectoderm (precursor of neural crest cells, which mainly form facial …

Autophagy is a highly conserved process from yeast to mammals in which intracellular
materials are engulfed by a double-membrane organelle called autophagosome and …

Bone is a dynamic organ that undergoes constant remodeling, an energetically costly
process by which old bone is replaced and localized bone defects are repaired to renew the …

Protein S-palmitoylation refers to a post-translational modification (PTM) wherein palmitic
acid, a 16-carbon long saturated fatty acid gets covalently attached to Cys sidechain of a …

S-Acylation is a major post-translational modification affecting several cellular processes. It
is particularly important for neuronal functions. This modification is catalyzed by a family of …

Palmitoyltransferase (PAT) catalyses protein S-palmitoylation which adds 16-carbon
palmitate to specific cysteines and contributes to various biological functions. We previously …

Contributing to bone loss with aging is a progressive reduction in osteoblast number and
function leading to decreased bone formation. In aging bone, mesenchymal stem cells …

Palmitoylation is an evolutionally conserved lipid modification of proteins. Dynamic and
reversible palmitoylation controls a wide range of molecular and cellular properties of …