Mitochondria have cell-type specific phenotypes, perform dozens of interconnected
functions and undergo dynamic and often reversible physiological recalibrations. Given their …

Efforts to understand how mitochondrial dysfunction contributes to neurodegeneration have
primarily focussed on the role of mitochondria in neuronal energy metabolism. However …

Mitochondria play a key role in both health and disease. Their function is not limited to
energy production but serves multiple mechanisms varying from iron and calcium …

Bone is one of the most common sites of tumor metastases. During the last step of bone
metastasis, cancer cells colonize and disrupt the bone matrix, which is maintained mainly by …

Temperature is a key abiotic factor affecting ecology, biogeography, and evolution of
species. Alterations of energy metabolism play an important role in adaptations and plastic …

Sarcopenia is a multifactorial condition related to the loss of muscle mass and strength due
to aging, eating habits, physical inactivity, or even caused by another disease. Affected …

Cellular homeostasis is intricately influenced by stimuli from the microenvironment, including
signaling molecules, metabolites, and pathogens. Functioning as a signaling hub within the …

Mitochondrial evolution: Gene shuffling, endosymbiosis, and signaling | Science Advances
news careers commentary Journals Science Science brought to you byGoogle Indexer Log in …

Serial focussed ion beam scanning electron microscopy (FIB/SEM) enables imaging and
assessment of subcellular structures on the mesoscale (10 nm to 10 µm). When applied to …

We review the findings that establish that perturbations of various aspects of mitochondrial
function, including oxidative phosphorylation, can promote lifespan extension, with different …