A great deal of experimental evidence suggests that ligands can stabilize different receptor
active states that go on to interact with cellular signaling proteins to form a range of different …

Abstract Missale, Cristina, S. Russel Nash, Susan W. Robinson, Mohamed Jaber, and Marc
G. Caron. Dopamine Receptors: From Structure to Function. Physiol. Rev. 78: 189–225 …

Disruption of the mouse dopamine transporter gene results in spontaneous hyperlocomotion
despite major adaptive changes, such as decreases in neurotransmitter and receptor levels …

Heterotrimeric G proteins are key players in transmembrane signaling by coupling a huge
variety of receptors to channel proteins, enzymes, and other effector molecules. Multiple …

Dopamine (DA) is the most abundant catecholamine in the brain. The involvement and
importance of DA as a neurotransmitter in the regulation of different physiological functions …

This article reviews findings up to the end of 1997 about the inducible transcription factors
(ITFs) c-Jun, JunB, JunD, c-Fos, FosB, Fra-1, Fra-2, Krox-20 (Egr-2) and Krox-24 (NGFI-A …

The striatum is composed principally of GABAergic, medium spiny striatal projection neurons
(MSNs) that can be categorized based on their gene expression, electrophysiological …

The basal ganglia, said Kinnear-Wilson in the 1920s, have all the clarity of a dark basement.
And so it has remained for the better part of a century. There are now major new ideas about …

Dopamine neurons of the substantia nigra and ventral tegmental area regulate movement
and affective behavior and degenerate in Parkinson's disease. The orphan nuclear receptor …

Brain-derived neurotrophic factor (BDNF) and its receptor TrkB regulate both short-term
synaptic functions and long-term potentiation (LTP) of brain synapses, raising the possibility …