Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide and
confers a poor prognosis. Beyond standard systemic therapy with multikinase inhibitors …

The IL-17 family is an evolutionarily old cytokine family consisting of six members (IL-17A
through IL-17F). IL-17 family cytokines signal through heterodimeric receptors that include …

γδ T cells have recently gained considerable attention as an attractive tool for cancer
adoptive immunotherapy due to their potent anti-tumor activity and unique role in …

Viral infections cause substantial human morbidity and mortality, and are a significant health
burden worldwide. Following a viral infection, the host may initiate complex antiviral immune …

Background Non-alcoholic fatty liver disease (NAFLD) is a common, chronic liver disease
worldwide. Recent studies have shown that T helper (Th) 17 and regulatory T (Treg) cells …

The contributions of γδ T-cells to immunity to infection or tumors critically depend on their
activation and differentiation into effectors capable of secreting cytokines and killing infected …

The pro-inflammatory cytokine interleukin (IL)-17 and IL-17-producing cells are important
players in the pathogenesis of many autoimmune/inflammatory diseases. More recently …

Chronic inflammatory liver diseases are often accompanied by behavior alterations
including fatigue, mood disorders, cognitive dysfunction and sleep disturbances. These …

Abstract Interleukin-17 (IL-17), a pleiotropic proinflammatory cytokine, is reported to be
significantly generated by a distinct subset of CD4+ T-cells, upgrading cancer-elicited …

Adoptive cell therapy (ACT) with engineered T cells has emerged as a promising strategy for
the treatment of malignant tumors. Among them, there is great interest in engineered γδ T …