Aliphatic three-and four-membered rings including cyclopropanes, cyclobutanes, oxetanes,
azetidines and bicyclo [1.1. 1] pentanes have been increasingly exploited in medicinal …

Highlights•Drug-likeness refers to the similarity between compounds and drugs; drug-like
compounds are more likely to be transformed into drugs.•Chemical structures with enhanced …

Cyclobutanes are increasingly used in medicinal chemistry in the search for relevant
biological properties. Important characteristics of the cyclobutane ring include its unique …

Tankyrases are multifunctional poly (adenosine diphosphate-ribose) polymerases that
regulate diverse biological processes including telomere maintenance and cellular …

Canonical WNT signaling is an important developmental pathway that has attracted
increased attention for anticancer drug discovery. From the production and secretion of WNT …

The interactions between proteins and ligands are involved in various biological functions.
While experimental structures provide key static structural information of ligand-unbound …

1, 2, 4-Triazole derivatives possess promising in vitro and in vivo anticancer activity, and
many anticancer agents such as fluconazole, tebuconazole, triadimefon, and ribavirin bear a …

Tankyrase 1 and 2 (TNKS1/2) catalyze post-translational modification by poly-ADP-
ribosylation of a plethora of target proteins. In this function, TNKS1/2 also impact the WNT/β …

The canonical WNT pathway plays an important role in cancer pathogenesis. Inhibition of
poly (ADP-ribose) polymerase catalytic activity of the tankyrases (TNKS/TNKS2) has been …

Tankyrases are the group of enzymes belonging to a class of Poly (ADP-ribose) polymerase
(PARP) recently named ADP-ribosyltransferase (ARTD). The two isoforms of tankyrase ie …