Bacteria as vectors for gene therapy of cancer

CK Baban, M Cronin, D O'Hanlon… - Bioengineered …, 2010 - Taylor & Francis
Anti-cancer therapy faces major challenges, particularly in terms of specificity of treatment.
The ideal therapy would eradicate tumour cells selectively with minimum side effects on …

[HTML][HTML] Hybrid biomicromotors

L Schwarz, M Medina-Sánchez… - Applied Physics Reviews, 2017 - pubs.aip.org
Micromotors are devices that operate at the microscale and convert energy to motion. Many
micromotors are microswimmers, ie, devices that can move freely in a liquid at a low …

[HTML][HTML] Bacteria-mediated delivery of nanoparticles and cargo into cells

D Akin, J Sturgis, K Ragheb, D Sherman… - Nature …, 2007 - nature.com
Nanoparticles and bacteria can be used, independently, to deliver genes and proteins into
mammalian cells for monitoring or altering gene expression and protein production. Here …

Listeria monocytogenes Promotes Tumor Growth via Tumor Cell Toll-Like Receptor 2 Signaling

B Huang, J Zhao, S Shen, H Li, KL He, GX Shen… - Cancer Research, 2007 - AACR
The contribution of bacterial infection to tumorigenesis is usually ascribed to infection-
associated inflammation. An alternate view is that direct interaction of bacteria with tumor …

Lactococcus lactis as a live vector: heterologous protein production and DNA delivery systems

DS Pontes, MSP De Azevedo, JM Chatel… - Protein expression and …, 2011 - Elsevier
Lactic acid bacteria (LAB), widely used in the food industry, are present in the intestine of
most animals, including humans. The potential use of these bacteria as mucosal delivery …

Bacteria and tumours: causative agents or opportunistic inhabitants?

J Cummins, M Tangney - Infectious agents and cancer, 2013 - Springer
Associations between different bacteria and various tumours have been reported in patients
for decades. Studies involving characterisation of bacteria within tumour tissues have …

Drug delivery to the inflamed intestinal mucosa–targeting technologies and human cell culture models for better therapies of IBD

O Hartwig, MAS Boushehri, KS Shalaby… - Advanced Drug Delivery …, 2021 - Elsevier
Current treatment strategies for inflammatory bowel disease (IBD) seek to alleviate the
undesirable symptoms of the disorder. Despite the higher specificity of newer generation …

High Resolution In Vivo Bioluminescent Imaging for the Study of Bacterial Tumour Targeting

M Cronin, AR Akin, SA Collins, J Meganck, JB Kim… - PloS one, 2012 - journals.plos.org
The ability to track microbes in real time in vivo is of enormous value for preclinical
investigations in infectious disease or gene therapy research. Bacteria present an attractive …

Orally administered bifidobacteria as vehicles for delivery of agents to systemic tumors

M Cronin, D Morrissey, S Rajendran, SM El Mashad… - Molecular Therapy, 2010 - cell.com
Certain bacteria have emerged as biological gene vectors with natural tumor specificity,
capable of specifically delivering genes or gene products to the tumor environment when …

Improved Luciferase Tagging System for Listeria monocytogenes Allows Real-Time Monitoring In Vivo and In Vitro

CU Riedel, IR Monk, PG Casey… - Applied and …, 2007 - Am Soc Microbiol
An improved system for luciferase tagging Listeria monocytogenes was developed by
constructing a highly active, constitutive promoter. This construct gave 100-fold-higher …