γδ T cells: origin and fate, subsets, diseases and immunotherapy

Y Hu, Q Hu, Y Li, L Lu, Z Xiang, Z Yin… - … and Targeted Therapy, 2023 - nature.com
The intricacy of diseases, shaped by intrinsic processes like immune system exhaustion and
hyperactivation, highlights the potential of immune renormalization as a promising strategy …

Translating gammadelta (γδ) T cells and their receptors into cancer cell therapies

Z Sebestyen, I Prinz, J Déchanet-Merville… - Nature reviews Drug …, 2020 - nature.com
Clinical responses to checkpoint inhibitors used for cancer immunotherapy seemingly
require the presence of αβT cells that recognize tumour neoantigens, and are therefore …

Allogeneic CD20‐targeted γδ T cells exhibit innate and adaptive antitumor activities in preclinical B‐cell lymphoma models

KP Nishimoto, T Barca, A Azameera… - Clinical & …, 2022 - Wiley Online Library
Objectives Autologous chimeric antigen receptor (CAR) αβ T‐cell therapies have
demonstrated remarkable antitumor efficacy in patients with haematological malignancies; …

γδ T cells in the tumor microenvironment—Interactions with other immune cells

KF Chan, JDG Duarte, S Ostrouska… - Frontiers in …, 2022 - frontiersin.org
A growing number of studies have shown that γδ T cells play a pivotal role in mediating the
clearance of tumors and pathogen-infected cells with their potent cytotoxic, cytolytic, and …

Dissecting the biology of allogeneic HSCT to enhance the GvT effect whilst minimizing GvHD

BR Blazar, GR Hill, WJ Murphy - Nature Reviews Clinical Oncology, 2020 - nature.com
Allogeneic haematopoietic stem cell transplantation (allo-HSCT) was the first successful
therapy for patients with haematological malignancies, predominantly owing to graft-versus …

The potential role of γδ T cells after allogeneic HCT for leukemia

R Handgretinger, K Schilbach - Blood, The Journal of the …, 2018 - ashpublications.org
Allogeneic hematopoetic stem cell transplantation (HCT) offers an option for patients with
hematologic malignancies, in whom conventional standard therapies failed or are not …

MAIT and Vδ2 unconventional T cells are supported by a diverse intestinal microbiome and correlate with favorable patient outcome after allogeneic HCT

H Andrlová, O Miltiadous, AI Kousa, A Dai… - Science translational …, 2022 - science.org
Microbial diversity is associated with improved outcomes in recipients of allogeneic
hematopoietic cell transplantation (allo-HCT), but the mechanism underlying this …

[HTML][HTML] Comparison of immune reconstitution between anti-T-lymphocyte globulin and posttransplant cyclophosphamide as acute graft-versus-host disease …

R Massoud, N Gagelmann… - …, 2021 - pmc.ncbi.nlm.nih.gov
Anti-T-cell lymphocyte globulin (ATLG) and posttransplant cyclophosphamide (PTCy) are
now widely used strategies to prevent graft-versus-host disease (GVHD) after allogeneic …

Reconstitution of T cell subsets following allogeneic hematopoietic cell transplantation

L Dekker, C de Koning, C Lindemans, S Nierkens - Cancers, 2020 - mdpi.com
Allogeneic (allo) hematopoietic cell transplantation (HCT) is the only curative treatment
option for patients suffering from chemotherapy-refractory or relapsed hematological …

Interleukin-15 enhances the proliferation, stimulatory phenotype, and antitumor effector functions of human gamma delta T cells

HH Van Acker, S Anguille, Y Willemen… - Journal of hematology & …, 2016 - Springer
Background Adoptive immunotherapy is gaining momentum to fight malignancies, whereby
γδ T cells have received recent attention as an alternative cell source as to natural killer cells …