Arachidonic acid metabolism and kidney inflammation
As a major component of cell membrane lipids, Arachidonic acid (AA), being a major
component of the cell membrane lipid content, is mainly metabolized by three kinds of …
component of the cell membrane lipid content, is mainly metabolized by three kinds of …
Soluble epoxide hydrolase as a therapeutic target for pain, inflammatory and neurodegenerative diseases
KM Wagner, CB McReynolds, WK Schmidt… - Pharmacology & …, 2017 - Elsevier
Eicosanoids are biologically active lipid signaling molecules derived from polyunsaturated
fatty acids. Many of the actions of eicosanoid metabolites formed by cyclooxygenase and …
fatty acids. Many of the actions of eicosanoid metabolites formed by cyclooxygenase and …
Therapeutic potential of omega-3 fatty acid-derived epoxyeicosanoids in cardiovascular and inflammatory diseases
WH Schunck, A Konkel, R Fischer… - Pharmacology & …, 2018 - Elsevier
Numerous benefits have been attributed to dietary long-chain omega-3 polyunsaturated fatty
acids (n-3 LC-PUFAs), including protection against cardiac arrhythmia, triglyceride-lowering …
acids (n-3 LC-PUFAs), including protection against cardiac arrhythmia, triglyceride-lowering …
Multi-target approaches in metabolic syndrome
FF Lillich, JD Imig, E Proschak - Frontiers in pharmacology, 2021 - frontiersin.org
Metabolic syndrome (MetS) is a highly prevalent disease cluster worldwide. It requires
polypharmacological treatment of the single conditions including type II diabetes …
polypharmacological treatment of the single conditions including type II diabetes …
Synthesis and significance of arachidonic acid, a substrate for cyclooxygenases, lipoxygenases, and cytochrome P450 pathways in the tumorigenesis of glioblastoma …
J Korbecki, E Rębacz-Maron, P Kupnicka, D Chlubek… - Cancers, 2023 - mdpi.com
Simple Summary Glioblastoma multiforme is a brain tumor with a very unfavorable
prognosis, where the vast majority of patients do not survive a year after diagnosis. One line …
prognosis, where the vast majority of patients do not survive a year after diagnosis. One line …
The role of epoxyeicosatrienoic acids in cardiac remodeling
J Lai, C Chen - Frontiers in physiology, 2021 - frontiersin.org
Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid by cytochrome P450
(CYP) epoxygenases, which include four regioisomers: 5, 6-EET, 8, 9-EET, 11, 12-EET, and …
(CYP) epoxygenases, which include four regioisomers: 5, 6-EET, 8, 9-EET, 11, 12-EET, and …
Effects of adamantane alterations on soluble epoxide hydrolase inhibition potency, physical properties and metabolic stability
V Burmistrov, C Morisseau, TR Harris, G Butov… - Bioorganic …, 2018 - Elsevier
Adamantyl groups are widely used in medicinal chemistry. However, metabolism limits their
usage. Herein, we report the first systematic study of adamantyl ureas and diureas bearing …
usage. Herein, we report the first systematic study of adamantyl ureas and diureas bearing …
Soluble epoxide hydrolase inhibitors: an overview and patent review from the last decade
Introduction Biological effects mediated by the CYP450 arm of arachidonate cascade
implicate the enzyme-soluble epoxide hydrolase (sEH) in hydrolyzing anti-inflammatory …
implicate the enzyme-soluble epoxide hydrolase (sEH) in hydrolyzing anti-inflammatory …
CYP2J2 molecular recognition: a new axis for therapeutic design
Cytochrome P450 (CYP) epoxygenases are a special subset of heme-containing CYP
enzymes capable of performing the epoxidation of polyunsaturated fatty acids (PUFA) and …
enzymes capable of performing the epoxidation of polyunsaturated fatty acids (PUFA) and …
Relative importance of soluble and microsomal epoxide hydrolases for the hydrolysis of epoxy-fatty acids in human tissues
Epoxy-fatty acids (EpFAs) are endogenous lipid mediators that have a large breadth of
biological activities, including the regulation of blood pressure, inflammation, angiogenesis …
biological activities, including the regulation of blood pressure, inflammation, angiogenesis …