Standard treatment of primary and metastatic brain tumours includes high-dose
megavoltage-range radiation to the cranial vault. About half of patients survive> 6 months …

Adult neurogenesis in the hippocampus is a notable process due not only to its uniqueness
and potential impact on cognition but also to its localized vertical integration of different …

This study shows for the first time that normal brain tissue toxicities after WBI can be reduced
with increased dose rate. Spatial memory is preserved after WBI with mean dose rates …

Approximately 100,000 primary and metastatic brain tumor patients/year in the US survive
long enough (> 6 months) to experience radiation-induced brain injury. Prior to 1970, the …

The integration of adult-born neurons into the circuitry of the adult hippocampus suggests an
important role for adult hippocampal neurogenesis in learning and memory, but its specific …

This report provides a review of early and late effects of radiation in normal tissues and
organs with respect to radiation protection. It was instigated following a recommendation in …

The generation of new neurons is sustained throughout adulthood in the mammalian brain
due to the proliferation and differentiation of adult neural stem cells. In this review, we …

Continued improvements in cancer therapies have increased the number of long-term
cancer survivors. Radiation therapy remains one of the primary treatment modalities with …

Cranial irradiation for the treatment of brain cancer elicits progressive and severe cognitive
dysfunction that is associated with significant neuropathology. Radiation injury in the CNS …

Adolescence represents a critical period for brain and behavioural health and characterised
by the onset of mood, psychotic and anxiety disorders. In rodents, neurogenesis is very …