Adult stem cells hold many promises for future clinical applications and regenerative
medicine. The haematopoietic stem cell (HSC) is the best-characterized somatic stem cell so …

The mechanisms of bone and blood formation have traditionally been viewed as distinct,
unrelated processes, but compelling evidence suggests that they are intertwined. Based on …

The epidermis is believed to contain two types of proliferating cells: stem cells and cells with
a lower capacity for self-renewal and higher probability of undergoing terminal …

Cell divisions during embryonic development give rise to new differentiated cell types or
increase the total number of cells in the embryo. In contrast, the major role of cell division in …

Differentiation, leading to ce~ llular diversity, is crucial to the function of metazoa. It
continues to be a central biological problem. Explanations of differentiation should begin …

An infectious retrovirus vector has been used to transfer a bacterial gene encoding
resistance to the neomycin analogue G418 into pluripotent haematopoietic stem cells …

A method described to purify pluripotent hemopoietic stem cells (PHSC) from adult mouse
bone marrow. The method consists of three separation steps. First, bone marrow cells are …

The bone marrow contains branching vascular sinuses lying in a fibroblastic stroma which
supports hematopoiesis. This paper describes the stroma and vascular sinuses by scanning …

Certain cells (CFU-S) in the haematopoietic tissues of mice are able to form macroscopic
nodules in the spleen 7–14 days after injection in heavily irradiated recipient mice1. At 7–9 …

In heavily irradiated mice, bone marrow regeneration of either endogenous or exogenous
origin was shown to occur in discrete foci comparable to the more intensively studied spleen …