Crosstalk between lipid metabolism and bone homeostasis: exploring intricate signaling relationships

H Xiao, W Li, Y Qin, Z Lin, C Qian, M Wu, Y Xia, J Bai… - Research, 2024 - spj.science.org
Bone is a dynamic tissue reshaped by constant bone formation and bone resorption to
maintain its function. The skeletal system accounts for approximately 70% of the total volume …

Influence of cholesterol on the regulation of osteoblast function

A Akhmetshina, D Kratky, E Rendina-Ruedy - Metabolites, 2023 - mdpi.com
Bone is a dynamic tissue composed of cells, an extracellular matrix, and mineralized portion.
Osteoblasts are responsible for proper bone formation and remodeling, and function. These …

Preferential formation of human heteromeric SK2: SK3 channels limits homomeric SK channel assembly and function

AS Butler, JC Hancox, NV Marrion - Journal of Biological Chemistry, 2023 - ASBMB
Three isoforms of small conductance, calcium-activated potassium (SK) channel subunits
have been identified (SK1-3) that exhibit a broad and overlapping tissue distribution. SK …

Low-density lipoprotein cholesterol and statin usage are associated with rates of pseudarthrosis following single-level posterior lumbar interbody fusion

MS Lavu, NB Eghrari, PS Makineni, DC Kaelber… - Spine, 2024 - journals.lww.com
Study design. Retrospective cohort study. Objective. To investigate the relationships of low-
density lipoprotein cholesterol and statin usage with pseudarthrosis following single-level …

[HTML][HTML] High cholesterol disorders, myocardial infarction and its therapeutics

RK Upadhyay - World Journal of Cardiovascular Diseases, 2023 - scirp.org
The current review article discusses several conditions linked to high cholesterol, including
their causes, diagnoses, and treatments. Cardiovascular disease is one of the leading …

Acute hyperlipidemia has transient effects on large-scale bone regeneration in male mice

L Yamamoto de Almeida, C Dietrich, O Duverger… - Scientific Reports, 2024 - nature.com
Excessive dietary fat intake increases plasma lipid levels and has been associated with
reduced bone mineral density (BMD) and increased risk of osteoporotic fracture, especially …

Hyperlipidemia impairs bone repair and regeneration via miR-193a-3p/STMN1/PI3K/Akt axis

J Shang, Z Li, A Ma, T Zhu, G Ma, H Gui, H Ren… - Biochemical …, 2025 - Elsevier
Hyperlipidemia, a metabolic disease characterized by excessive blood lipid, disturbs bone
metabolism by shifting cell fate of bone marrow stromal cells (BMSCs) towards adipogenic …

Sesamol improves bone mass in ovary intact growing and adult rats but accelerates bone deterioration in the ovariectomized rats

K Patel, SR Mangu, SV Sukhdeo, K Sharan - The Journal of Nutritional …, 2023 - Elsevier
Sesamol, an active component in sesame seeds, is known for its health benefits. However,
its effect on bone metabolism remains unexplored. The present study aims to investigate the …

Geniposide alleviates cholesterol-induced endoplasmic reticulum stress and apoptosis in osteoblasts by mediating the GLP-1R/ABCA1 pathway

M Zhong, Z Wu, Z Chen, L Wu, J Zhou - Journal of Orthopaedic Surgery …, 2024 - Springer
Background Cholesterol (CHO) is an essential component of the body. However, high CHO
levels in the body can damage bone mass and promote osteoporosis. CHO accumulation …

[HTML][HTML] Assessment of the osteogenic effect after maxillary sinus floor elevation and simultaneous implantation with or without bone grafts by analyzing trabecular …

M Wang, B Li, H Feng, Q Ye, Y Sun… - Journal of Applied Oral …, 2024 - SciELO Brasil
Objective: The aim of this population-based retrospective study was to compare the
osteogenic effect of newly formed bone after maxillary sinus floor elevation (MSFE) and …