Advances in surgical procedures, technology, and immune suppression have transformed
organ transplantation. However, the metabolic changes that occur during organ retrieval …

Heart transplantation has become the accepted treatment for advanced heart failure, with
over 4000–5000 performed in the world annually. Although the number of yearly transplants …

Background and Aims Itaconate, a metabolite of the tricarboxylic acid cycle, plays anti‐
inflammatory roles in macrophages during endotoxemia. The mechanisms underlying its …

The use of donation after circulatory death (DCD) liver allografts has been constrained by
limitations in the duration of donor warm ischemia time (DWIT), donor agonal time (DAT) …

Preservation of human organs at subzero temperatures has been an elusive goal for
decades. The major complication hindering successful subzero preservation is the formation …

Background and Aims Cholangiocarcinoma (CCA) is a highly malignant epithelial tumor of
the biliary tree with poor prognosis. In the current study, we present evidence that the …

Background Biliary atresia (BA) remains the number one indication for paediatric liver
transplantation (LT) worldwide but is an uncommon indication for older LT recipients. The …

In the current scope of extended preservation protocols, high subzero approaches of VCA
grafts will be particularly critical enabling technologies for the implementation of tolerance …

Abstract Hypothermic Oxygenated machine PErfusion (HOPE) has recently emerged as a
preservation technique which can reduce ischemic injury and improve clinical outcomes …

The significance of human leukocyte antigen (HLA) matching and preformed donor-specific
antibodies (DSAs) in liver transplantation remains unclear. The aim of this study was to …