Hepatic encephalopathy: Novel insights into classification, pathophysiology and therapy

CF Rose, P Amodio, JS Bajaj, RK Dhiman… - Journal of …, 2020 - Elsevier
Hepatic encephalopathy (HE) is a frequent and serious complication of both chronic liver
disease and acute liver failure. HE manifests as a wide spectrum of neuropsychiatric …

[HTML][HTML] The systemic inflammation hypothesis: towards a new paradigm of acute decompensation and multiorgan failure in cirrhosis

V Arroyo, P Angeli, R Moreau, R Jalan, J Clària… - Journal of …, 2021 - Elsevier
Acute decompensation (AD) of cirrhosis is defined by the development of ascites, hepatic
encephalopathy (HE) and/or variceal bleeding. Ascites is traditionally attributed to …

Sarcopenia from mechanism to diagnosis and treatment in liver disease

S Dasarathy, M Merli - Journal of hepatology, 2016 - Elsevier
Sarcopenia or loss of skeletal muscle mass is the major component of malnutrition and is a
frequent complication in cirrhosis that adversely affects clinical outcomes. These include …

[HTML][HTML] Hepatic encephalopathy: a critical current review

A Hadjihambi, N Arias, M Sheikh, R Jalan - Hepatology international, 2018 - Springer
Hepatic encephalopathy (HE) is a serious neuropsychiatric complication of cirrhosis and/or
porto-systemic shunting. The clinical symptoms are widely variable, extending from subtle …

New clinical and pathophysiological perspectives defining the trajectory of cirrhosis

R Jalan, G D'Amico, J Trebicka, R Moreau, P Angeli… - Journal of …, 2021 - Elsevier
Traditionally, the complications of cirrhosis, namely variceal bleeding, ascites and hepatic
encephalopathy, were thought to result predominantly from circulatory dysfunction and …

Decoding the contributions of gut microbiota and cerebral metabolism in acute liver injury mice with and without cognitive dysfunction

T Sun, H Du, Z Li, J Xiong, Y Liu, Y Li… - CNS Neuroscience …, 2023 - Wiley Online Library
Aims Patients with acute liver injury (ALI) can develop cognitive dysfunction (CD). The study
investigated the role of gut microbiota and cerebral metabolism in ALI mice with and without …

[HTML][HTML] Neurotoxic agent-induced injury in neurodegenerative disease model: Focus on involvement of glutamate receptors

M Jakaria, SY Park, ME Haque… - Frontiers in molecular …, 2018 - frontiersin.org
Glutamate receptors play a crucial role in the central nervous system and are implicated in
different brain disorders. They play a significant role in the pathogenesis of …

[HTML][HTML] Active clinical trials in hepatic encephalopathy: something old, something new and something borrowed

T Balzano - Neurochemical Research, 2023 - Springer
Hepatic encephalopathy (HE) is a potentially reversible neurocognitive syndrome that
occurs in patients with acute or chronic liver disease. Currently, most of the therapies for HE …

Loss of paraspinal muscle mass is a gender‐specific consequence of cirrhosis that predicts complications and death

C Engelmann, S Schob… - Alimentary …, 2018 - Wiley Online Library
Background Loss of skeletal muscle mass is a recognised complication with a prognostic
impact in patients with cirrhosis. Aim To explore in a retrospective analysis which muscle …

[HTML][HTML] Management of hepatic encephalopathy associated with advanced liver disease

R García-Martínez, R Diaz-Ruiz, M Poncela - Clinical Drug Investigation, 2022 - Springer
Hepatic encephalopathy (HE) is a very prevalent condition in patients with advanced liver
disease and has a high recurrence rate. The pathophysiology has a multifactorial origin …