Aging is driven by hallmarks fulfilling the following three premises:(1) their age-associated
manifestation,(2) the acceleration of aging by experimentally accentuating them, and (3) the …

Nutriments have been deemed to impact all physiopathologic processes. Recent evidences
in molecular medicine and clinical trials have demonstrated that adequate nutrition …

Caloric restriction and intermittent fasting prolong the lifespan and healthspan of model
organisms and improve human health. The natural polyamine spermidine has been similarly …

Spermidine (SPD) delays age-related pathologies in various organisms. SPD
supplementation overcame the impaired immunotherapy against tumors in aged mice by …

Aging involves the systemic deterioration of all known cell types in most eukaryotes. Several
recently discovered compounds that extend the healthspan and lifespan of model organisms …

The polyamines putrescine, spermidine, and spermine are abundant polycations of vital
importance in mammalian cells. Their cellular levels are tightly regulated by degradation …

Spermidine is a natural polyamine that has health benefits and extends life span in several
species. Deoxyhypusine synthase (DHPS) and deoxyhypusine hydroxylase (DOHH) are key …

Background Deposition of amyloid beta (Aβ) and hyperphosphorylated tau along with glial
cell-mediated neuroinflammation are prominent pathogenic hallmarks of Alzheimer's …

Spermidine, a natural autophagy inducer, has a variety of health effects, such as antitumor,
antiaging, anti‐inflammation, cardiovascular protection, and neuromodulation. It has been a …

The human gut microbiota plays numerous roles in regulating host growth, the immune
system, and metabolism. Age-related changes in the gut environment lead to chronic …