Hyperphosphorylated tau aggregates, also known as neurofibrillary tangles, are a hallmark
neuropathological feature of Alzheimer's disease (AD). Molecular imaging of tau by positron …

Abstract Purpose In 2017, the Geneva Alzheimer's disease (AD) strategic biomarker
roadmap initiative proposed a framework of the systematic validation AD biomarkers to …

Tau PET tracers exhibit varying levels of specific signal and distinct off-target binding
patterns that are more diverse than amyloid PET tracers. This study compared 2 frequently …

Next to amyloid and tau, synaptic loss is a key pathological hallmark in Alzheimer's disease,
closely related to cognitive dysfunction and neurodegeneration. Tau is thought to cause …

This article presents an overview of imaging agents for PET that have been applied for
research and diagnostic purposes in patients affected by dementia. Classified by the target …

Abnormal accumulation of Tau protein is closely associated with neurodegeneration and
cognitive impairment and it is a biomarker of neurodegeneration in the dementia field …

Background The positron emission tomography (PET) radiotracer [18F] MK‐6240 exhibits
high specificity for neurofibrillary tangles (NFTs) of tau protein in Alzheimer's disease (AD) …

[18F] MK-6240 is a second-generation tau PET-tracer to quantify neurofibrillary tangles in-
vivo. However, individually variable levels of meningeal uptake induce spill-in-effects into …

[18F] MK-6240 meningeal/extracerebral off-target binding may impact tau quantification. We
examined the kinetics and longitudinal changes of extracerebral and reference regions.[18F] …

In this review we examine, in the context of the amyloid, tau, and neurodegeneration
framework, the available evidence and potential alternatives on how to establish tau …