Dynein at the kinetochore
R Gassmann - Journal of cell science, 2023 - journals.biologists.com
The microtubule minus-end-directed motility of cytoplasmic dynein 1 (dynein), arguably the
most complex and versatile cytoskeletal motor, is harnessed for diverse functions, such as …
most complex and versatile cytoskeletal motor, is harnessed for diverse functions, such as …
Bub1 kinase in the regulation of mitosis
Accurate chromosome segregation is required for cell survival and organismal development.
During mitosis, the spindle assembly checkpoint acts as a safeguard to maintain the high …
During mitosis, the spindle assembly checkpoint acts as a safeguard to maintain the high …
RZZ‐Spindly and CENP‐E form an integrated platform to recruit dynein to the kinetochore corona
Chromosome biorientation on the mitotic spindle is prerequisite to errorless genome
inheritance. CENP‐E (kinesin‐7) and dynein–dynactin (DD), microtubule motors with …
inheritance. CENP‐E (kinesin‐7) and dynein–dynactin (DD), microtubule motors with …
Structure of the RZZ complex and molecular basis of Spindly‐driven corona assembly at human kinetochores
In metazoans, a≈ 1 megadalton (MDa) multiprotein complex comprising the dynein–
dynactin adaptor Spindly and the ROD–Zwilch–ZW10 (RZZ) complex is the building block of …
dynactin adaptor Spindly and the ROD–Zwilch–ZW10 (RZZ) complex is the building block of …
PLK1 promotes the mitotic surveillance pathway by controlling cytosolic 53BP1 availability
M Burigotto, V Vigorito, C Gliech, A Mattivi, S Ghetti… - EMBO …, 2023 - embopress.org
Abstract 53BP1 acts at the crossroads between DNA repair and p53‐mediated stress
response. With its interactors p53 and USP28, it is part of the mitotic surveillance (or mitotic …
response. With its interactors p53 and USP28, it is part of the mitotic surveillance (or mitotic …
Synergistic stabilization of microtubules by BUB-1, HCP-1, and CLS-2 controls microtubule pausing and meiotic spindle assembly
During cell division, chromosome segregation is orchestrated by a microtubule-based
spindle. Interaction between spindle microtubules and kinetochores is central to the bi …
spindle. Interaction between spindle microtubules and kinetochores is central to the bi …
A farnesyl-dependent structural role for CENP-E in expansion of the fibrous corona
Correct chromosome segregation during cell division depends on proper connections
between spindle microtubules and kinetochores. During prometaphase, kinetochores are …
between spindle microtubules and kinetochores. During prometaphase, kinetochores are …
CENP-F stabilizes kinetochore-microtubule attachments and limits dynein stripping of corona cargoes
P Auckland, E Roscioli, HLE Coker… - Journal of Cell Biology, 2020 - rupress.org
Accurate chromosome segregation demands efficient capture of microtubules by
kinetochores and their conversion to stable bioriented attachments that can congress and …
kinetochores and their conversion to stable bioriented attachments that can congress and …
Electroporated recombinant proteins as tools for in vivo functional complementation, imaging and chemical biology
Delivery of native or chemically modified recombinant proteins into mammalian cells shows
promise for functional investigations and various technological applications, but concerns …
promise for functional investigations and various technological applications, but concerns …
The C-terminal helix of BubR1 is essential for CENP-E-dependent chromosome alignment
During cell division, misaligned chromosomes are captured and aligned by motors before
their segregation. The CENP-E motor is recruited to polar unattached kinetochores to …
their segregation. The CENP-E motor is recruited to polar unattached kinetochores to …