Metabolic homeostasis in mammals is tightly regulated by the complementary actions of
insulin and glucagon. The secretion of these hormones from pancreatic β-cells and α-cells …

Insulin and glucagon exert opposing effects on glucose metabolism and, consequently,
pancreatic islet β-cells and α-cells are considered functional antagonists. The intra-islet …

The pancreatic β-cell plays a key role in glucose homeostasis by secreting insulin, the only
hormone capable of lowering the blood glucose concentration. Impaired insulin secretion …

Islets of Langerhans are islands of endocrine cells scattered throughout the pancreas. A
number of new studies have pointed to the potential for conversion of non-β islet cells in to …

The somatostatin-secreting δ-cells comprise~ 5% of the cells of the pancreatic islets. The δ-
cells have complex morphology and might interact with many more islet cells than …

Diabetes is a major global problem. During the past decade, the genetic basis of various
monogenic forms of the disease, and their underlying molecular mechanisms, have been …

Hundred years after the discovery of glucagon, its biology remains enigmatic. Accurate
measurement of glucagon has been essential for uncovering its pathological hypersecretion …

The inability of pancreatic β-cells to make sufficient insulin to control blood sugar is a central
feature of the aetiology of most forms of diabetes. In this review we focus on the deleterious …

In the pancreatic islet, serotonin is an autocrine signal increasing beta cell mass during
metabolic challenges such as those associated with pregnancy or high-fat diet. It is still …

Islet non-β-cells, the α-δ-and pancreatic polypeptide cells (PP-cells), are important
components of islet architecture and intercellular communication. In α-cells, glucagon is …