Macromolecular crowding is more than hard-core repulsions
Cells are crowded, but proteins are almost always studied in dilute aqueous buffer. We
review the experimental evidence that crowding affects the equilibrium thermodynamics of …
review the experimental evidence that crowding affects the equilibrium thermodynamics of …
When phased without water: biophysics of cellular desiccation, from biomolecules to condensates
The molecular machinery that enables life has evolved in water, yet many of the organisms
around us are able to survive even extreme desiccation. Especially remarkable are single …
around us are able to survive even extreme desiccation. Especially remarkable are single …
Zwitterionic osmolyte‐based hydrogels with antifreezing property, high conductivity, and stable flexibility at subzero temperature
Conductive hydrogels have emerged as fascinating materials applied in flexible electronics
because of their integrated conductivity and mechanical flexibility. However, the large …
because of their integrated conductivity and mechanical flexibility. However, the large …
Zwitterionic hydrogel with high transparency, ultrastretchability, and remarkable freezing resistance for wearable strain sensors
Multifunctional hydrogel with outstanding conductivity and mechanical flexibility has
received enormous attention as wearable electronic devices. However, fabricating …
received enormous attention as wearable electronic devices. However, fabricating …
Role of the extremolytes ectoine and hydroxyectoine as stress protectants and nutrients: genetics, phylogenomics, biochemistry, and structural analysis
Fluctuations in environmental osmolarity are ubiquitous stress factors in many natural
habitats of microorganisms, as they inevitably trigger osmotically instigated fluxes of water …
habitats of microorganisms, as they inevitably trigger osmotically instigated fluxes of water …
Antifreezing/Antiswelling Hydrogels: Synthesis Strategies and Applications as Flexible Motion Sensors
Y Wang, X Gao, J Wu, M Jiang, H Zhang… - ACS Applied Materials …, 2024 - ACS Publications
Hydrogels are excellent materials for fabricating flexible electronic devices, such as flexible
sensors. However, obtaining hydrogels with superior swelling capacity and good …
sensors. However, obtaining hydrogels with superior swelling capacity and good …
Osmolytes: Wonder molecules to combat protein misfolding against stress conditions
The proper functioning of any protein depends on its three dimensional conformation which
is achieved by the accurate folding mechanism. Keeping away from the exposed stress …
is achieved by the accurate folding mechanism. Keeping away from the exposed stress …
Chemical interactions of polyethylene glycols (PEGs) and glycerol with protein functional groups: applications to effects of PEG and glycerol on protein processes
DB Knowles, IA Shkel, NM Phan, M Sternke… - Biochemistry, 2015 - ACS Publications
In this work, we obtain the data needed to predict chemical interactions of polyethylene
glycols (PEGs) and glycerol with proteins and related organic compounds and thereby …
glycols (PEGs) and glycerol with proteins and related organic compounds and thereby …
A natural deep eutectic solvent formulated to stabilize β-lactam antibiotics
B Olivares, F Martínez, L Rivas, C Calderón… - Scientific reports, 2018 - nature.com
Abstract β-lactam antibiotics, such as penicillin share a very unstable chemical structure. In
water-based solutions, such as those used for clinical applications, the β-lactam ring is …
water-based solutions, such as those used for clinical applications, the β-lactam ring is …
Quantitative assessments of the distinct contributions of polypeptide backbone amides versus side chain groups to chain expansion via chemical denaturation
In aqueous solutions with high concentrations of chemical denaturants such as urea and
guanidinium chloride (GdmCl) proteins expand to populate heterogeneous conformational …
guanidinium chloride (GdmCl) proteins expand to populate heterogeneous conformational …