Sp1‐like family is an expanding transcription factor family. Members of this family bind to the
GC‐box or GT‐box elements in the promoter/enhancers and regulate the expression of the …

In recent years, genome-wide analyses of patients have resulted in the identification of a
number of neurodevelopmental disorders. Several of them are caused by mutations in …

The molecular mechanisms that regulate the production and diversity of olfactory bulb
interneurons remain poorly understood. With the exception of the GABAergic/dopaminergic …

Background De novo mutations are emerging as an important cause of neurocognitive
impairment, and whole exome sequencing of case-parent trios is a powerful way of …

Background The alarming rise in the obesity epidemic and growing concern for the
pathologic consequences of the metabolic syndrome warrant great need for development of …

Pur-alpha is a ubiquitous multifunctional protein that is strongly conserved throughout
evolution, binds to both DNA and RNA and functions in the initiation of DNA replication …

The PURA gene encodes Pur-alpha, a 322 amino acid protein with repeated nucleic acid
binding domains that are highly conserved from bacteria through humans. PUR genes with …

PURA, also known as Pur-alpha, is an evolutionarily conserved DNA/RNA-binding protein
crucial for various cellular processes, including DNA replication, transcriptional regulation …

Neural tube defects including spina bifida are common and severe congenital disorders. In
mice, mutations in more than 200 genes can result in neural tube defects. We hypothesized …

The PUR domain is a nucleic acid-binding motif found in critical regulatory proteins of higher
eukaryotes and in certain species of bacteria. During investigations into mechanisms by …