Recent Advancements in Typical Friedel–Crafts Alkylation Reactions Focused on Targeting Arene Nucleophiles

S Singh, CK Hazra - Synthesis, 2023 - thieme-connect.com
This review delves into recent advances and significant breakthroughs in the field of the
catalytic Friedel–Crafts alkylation of targeted arenes or heteroarenes. Though a few earlier …

A recent update on the environment friendly methodologies to synthesize bis (indolyl) methane and 3, 3-di (3-indolyl)-2-indolone derivatives

P Kamboj, V Tyagi - Tetrahedron, 2023 - Elsevier
Indole, widely recognized as a versatile category of heterocyclic frameworks that contain
nitrogen is extensively employed in the synthesis of various organic compounds due to their …

Lewis Acid-Promoted Typical Friedel–Crafts Reactions Using DMSO as a Carbon Source

N Vodnala, S Singh, CK Hazra - The Journal of Organic Chemistry, 2022 - ACS Publications
This study reports a mild and efficient synthetic protocol for the synthesis of symmetrical and
unsymmetrical diarylmethanes (DAMs). Using DMSO as the C1 source and TMSOTf as the …

Cooperative Friedel–Crafts Alkylation of Electron‐Deficient Arenes via Catalyst Activation with Hexafluoroisopropanol

S Singh, S Mondal, V Tiwari… - … –A European Journal, 2023 - Wiley Online Library
A Friedel‐Crafts alkylation of electron‐deficient arenes with aldehydes through′′ catalyst
activation′′ is presented. Through hydrogen bonding interactions, the solvent 1, 1, 1, 3, 3 …

Graphene oxide-catalysed carbene-transfer reaction in water: a highly “green” and selective approach to access 3, 3′, 3′′-trisindoles

P Kamboj, V Tyagi - Green Chemistry, 2024 - pubs.rsc.org
The insertion or transfer of carbene using diazo compounds as a precursor is being used
widely to synthesize/functionalize different classes of organic compounds. Different types of …

Silyl Cation-Initiated, Brønsted Acid-Catalyzed Strategy toward Unsymmetrical 3, 3-Disubstituted 2-Oxindoles and Azonazine Cores

J Khan, N Yadav, A Tyagi, CK Hazra - The Journal of Organic …, 2022 - ACS Publications
Herein, a mild, metal-free, robust approach for synthesizing valuable and sterically
demanding unsymmetrical 3, 3-disubstituted 2-oxindoles via reductive cyclization of α …

Zingiber zerumbet: a green and ecofriendly natural surfactant for the synthesis of bis (indolyl) methane, tris-indoline and spirooxindole derivatives

A Sapkal, S Attar, J Chavan, A Kumbhar… - … Chemistry and Pharmacy, 2023 - Elsevier
The present study aimed to the greener and eco-friendly synthesis of bis (indolyl) methane,
tris-indoline, and spirooxindole derivatives in the natural surfactant of Zingiber zerumbet …

Asymmetric Nozaki-Hiyama-Kishi (NHK)-type reaction of isatins with aromatic iodides by cobalt catalysis

J Xiao, Y Zheng, Y Zhao, Z Shi, M Wang - Chinese Chemical Letters, 2024 - Elsevier
The asymmetric addition of aromatic organometallic compounds to the carbonyl group (C-3)
of isatins, catalyzed by transition metals, has emerged as a remarkably efficient method for …

Development of Transition‐Metal‐Free Lewis Acid‐Initiated Double Arylation of Aldehyde: A Facile Approach Towards the Total Synthesis of Anti‐Breast‐Cancer …

S Singh, R Mahato, P Sharma, N Yadav… - … A European Journal, 2022 - Wiley Online Library
This work describes a mild and robust double hydroarylation strategy for the synthesis of
symmetrical/unsymmetrical diaryl‐and triarylmethanes in excellent yields using Lambert salt …

Synthesis of unsymmetrical diaryl oxindoles/isoquinolinediones using 2-phenoxy-1 H-benzo [d] imidazole as an integrated diarylating reagent

G Xu, Y Wang, K Liu, Y Jiang, X Zhang… - Organic Chemistry …, 2023 - pubs.rsc.org
Presented herein is a novel synthesis of unsymmetrical 3, 3-diaryl oxindoles and 4, 4-diaryl
isoquinolinediones through the cascade reactions of 2-phenoxy-1H-benzo [d] imidazoles …