Origin and function of circulating plasmablasts during acute viral infections
K Fink - Frontiers in immunology, 2012 - frontiersin.org
Activated B cells proliferate and differentiate into antibody-producing cells, long-lived
plasma cells, and memory B cells after immunization or infection. Repeated encounter of the …
plasma cells, and memory B cells after immunization or infection. Repeated encounter of the …
[HTML][HTML] Who and when to vaccinate against influenza
P Buchy, S Badur - International Journal of Infectious Diseases, 2020 - Elsevier
Known since Hippocrates and of continuing public health importance, influenza remains a
major cause of morbidity and mortality worldwide, and large segments of the human …
major cause of morbidity and mortality worldwide, and large segments of the human …
Limited efficacy of inactivated influenza vaccine in elderly individuals is associated with decreased production of vaccine-specific antibodies
S Sasaki, M Sullivan, CF Narvaez… - The Journal of …, 2011 - Am Soc Clin Investig
During seasonal influenza epidemics, disease burden is shouldered predominantly by the
very young and the elderly. Elderly individuals are particularly affected, in part because …
very young and the elderly. Elderly individuals are particularly affected, in part because …
[HTML][HTML] Safety and immunogenicity of an oral tablet norovirus vaccine, a phase I randomized, placebo-controlled trial
L Kim, D Liebowitz, K Lin, K Kasparek, MF Pasetti… - JCI insight, 2018 - ncbi.nlm.nih.gov
BACKGROUND. Noroviruses are the leading cause of epidemic acute gastroenteritis and
foodborne diarrheal disease in humans. However, there are no approved vaccines for …
foodborne diarrheal disease in humans. However, there are no approved vaccines for …
[HTML][HTML] New approaches to understanding the immune response to vaccination and infection
The immune system is a network of specialized cell types and tissues that communicates via
cytokines and direct contact, to orchestrate specific types of defensive responses. Until …
cytokines and direct contact, to orchestrate specific types of defensive responses. Until …
The gracefully aging immune system
D Boraschi, MT Aguado, C Dutel, J Goronzy… - Science translational …, 2013 - science.org
Prolonged life expectancy in the 20th century has been one of humankind's greatest
triumphs. However, the substantial increase in the human life span has ushered in a new …
triumphs. However, the substantial increase in the human life span has ushered in a new …
High-throughput sequencing of natively paired antibody chains provides evidence for original antigenic sin shaping the antibody response to influenza vaccination
YC Tan, LK Blum, S Kongpachith, CH Ju, X Cai… - Clinical …, 2014 - Elsevier
We developed a DNA barcoding method to enable high-throughput sequencing of the
cognate heavy-and light-chain pairs of the antibodies expressed by individual B cells. We …
cognate heavy-and light-chain pairs of the antibodies expressed by individual B cells. We …
Vaccine based on folded receptor binding domain‐PreS fusion protein with potential to induce sterilizing immunity to SARS‐CoV‐2 variants
P Gattinger, B Kratzer, I Tulaeva, K Niespodziana… - Allergy, 2022 - Wiley Online Library
Background Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is
responsible for the ongoing global COVID‐19 pandemic. One possibility to control the …
responsible for the ongoing global COVID‐19 pandemic. One possibility to control the …
Antibody and plasmablast response to 13-valent pneumococcal conjugate vaccine in chronic lymphocytic leukemia patients–preliminary report
M Pasiarski, J Rolinski, E Grywalska… - PloS one, 2014 - journals.plos.org
Background Chronic lymphocytic leukemia (CLL) leads to significant immune system
dysfunction. The predominant clinical presentation in 50% of patients involves recurrent …
dysfunction. The predominant clinical presentation in 50% of patients involves recurrent …
Broad hemagglutinin-specific memory B cell expansion by seasonal influenza virus infection reflects early-life imprinting and adaptation to the infecting virus
Memory B cells (MBCs) are key determinants of the B cell response to influenza virus
infection and vaccination, but the effect of different forms of influenza antigen exposure on …
infection and vaccination, but the effect of different forms of influenza antigen exposure on …