Recognizing the importance of childhood maltreatment as a critical factor in psychiatric diagnoses, treatment, research, prevention, and education

MH Teicher, JB Gordon, CB Nemeroff - Molecular psychiatry, 2022 - nature.com
Childhood maltreatment is the most important preventable risk factor for psychiatric
disorders. Maltreated individuals typically develop psychiatric disorders at an earlier age …

Major depressive disorder: advances in neuroscience research and translational applications

Z Li, M Ruan, J Chen, Y Fang - Neuroscience bulletin, 2021 - Springer
Major depressive disorder (MDD), also referred to as depression, is one of the most common
psychiatric disorders with a high economic burden. The etiology of depression is still not …

ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries

PM Thompson, N Jahanshad, CRK Ching… - Translational …, 2020 - nature.com
This review summarizes the last decade of work by the ENIGMA (E nhancing N euro I
maging G enetics through M eta A nalysis) Consortium, a global alliance of over 1400 …

Early adversity and development: parsing heterogeneity and identifying pathways of risk and resilience

DG Gee - American Journal of Psychiatry, 2021 - Am Psychiatric Assoc
Adversity early in life is common and is a major risk factor for the onset of psychopathology.
Delineating the neurodevelopmental pathways by which early adversity affects mental …

ENIGMA MDD: seven years of global neuroimaging studies of major depression through worldwide data sharing

L Schmaal, E Pozzi, T C. Ho, LS Van Velzen… - Translational …, 2020 - nature.com
A key objective in the field of translational psychiatry over the past few decades has been to
identify the brain correlates of major depressive disorder (MDD). Identifying measurable …

[HTML][HTML] Altered resting-state functional connectome in major depressive disorder: a mega-analysis from the PsyMRI consortium

N Javaheripour, M Li, T Chand, A Krug… - Translational …, 2021 - nature.com
Major depressive disorder (MDD) is associated with abnormal neural circuitry. It can be
measured by assessing functional connectivity (FC) at resting-state functional MRI, that may …

Cross disorder comparisons of brain structure in schizophrenia, bipolar disorder, major depressive disorder, and 22q11. 2 deletion syndrome: a review of ENIGMA …

EJ Cheon, CE Bearden, D Sun… - Psychiatry and …, 2022 - Wiley Online Library
This review compares the main brain abnormalities in schizophrenia (SZ), bipolar disorder
(BD), major depressive disorder (MDD), and 22q11. 2 Deletion Syndrome (22q11DS) …

Reduced hippocampal gray matter volume is a common feature of patients with major depression, bipolar disorder, and schizophrenia spectrum disorders

K Brosch, F Stein, S Schmitt, JK Pfarr… - Molecular …, 2022 - nature.com
Major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia spectrum
disorder (SSD, schizophrenia, and schizoaffective disorder) overlap in symptomatology, risk …

Brain-based sex differences in depression: a systematic review of neuroimaging studies

S Mohammadi, H Seyedmirzaei, MA Salehi… - Brain Imaging and …, 2023 - Springer
Major depressive disorder (MDD) is a common psychiatric illness with a wide range of
symptoms such as mood decline, loss of interest, and feelings of guilt and worthlessness …

[HTML][HTML] The effect of adverse childhood experiences on chronic pain and major depression in adulthood: a systematic review and meta-analysis

G Antoniou, E Lambourg, JD Steele… - British Journal of …, 2023 - Elsevier
Background Adverse childhood experiences have been linked to increased multimorbidity,
with physical and mental health consequences throughout life. Chronic pain is often …