Bioinformatics and systems biology of the lipidome

S Subramaniam, E Fahy, S Gupta, M Sud… - Chemical …, 2011 - ACS Publications
Lipids play an important role in physiology and pathophysiology of living systems. Until a
few decades ago, the number of lipid molecules that were chemically characterized was a …

Lipid integration in neurodegeneration: an overview of Alzheimer's disease

RS Yadav, NK Tiwari - Molecular neurobiology, 2014 - Springer
Various types of lipids and their metabolic products associated with the biological
membrane play a crucial role in signal transduction, modulation, and activation of receptors …

[PDF][PDF] Use of bioinformatics tools in different spheres of life sciences

MA Mehmood, U Sehar, N Ahmad - … of Data Mining in Genomics & …, 2014 - researchgate.net
The pace, by which scientific knowledge is being produced and shared today, was never
been so fast in the past. Different areas of science are getting closer to each other to give …

Role of dyslipidemia in preeclampsia—A review of lipidomic analysis of blood, placenta, syncytiotrophoblast microvesicles and umbilical cord artery from women with …

D Wojcik-Baszko, K Charkiewicz… - Prostaglandins & Other …, 2018 - Elsevier
Preeclampsia is a complex disorder and the pathogenesis of it is still not fully understood.
The most commonly accepted theory of pathogenesis assumes that there occurs impaired …

Physical forces modulate cell differentiation and proliferation processes

L Schwartz, J da Veiga Moreira… - Journal of cellular and …, 2018 - Wiley Online Library
Currently, the predominant hypothesis explains cellular differentiation and behaviour as an
essentially genetically driven intracellular process, suggesting a gene‐centrism paradigm …

Aggregated alpha-synuclein transcriptionally activates pro-inflammatory canonical and non-canonical NF-κB signaling pathways in peripheral monocytic cells

F Bearoff, D Dhavale, P Kotzbauer, S Kortagere - Molecular immunology, 2023 - Elsevier
Parkinson's disease (PD) is a neurodegenerative disorder characterized by chronic
neuroinflammation, loss of dopaminergic neurons in the substantia nigra, and in several …

The Xanthomonas type III effector XopAP prevents stomatal closure by interfering with vacuolar acidification

L Liu, Y Li, Z Xu, H Chen, J Zhang… - Journal of Integrative …, 2022 - Wiley Online Library
Plant stomata close rapidly in response to a rise in the plant hormone abscisic acid (ABA) or
salicylic acid (SA) and after recognition of pathogen‐associated molecular patterns …

Data management strategies for multinational large-scale systems biology projects

W Wruck, M Peuker… - Briefings in …, 2014 - academic.oup.com
Good accessibility of publicly funded research data is essential to secure an open scientific
system and eventually becomes mandatory [Wellcome Trust will Penalise Scientists Who …

Simultaneous quantification of serum nonesterified and esterified fatty acids as potential biomarkers to differentiate benign lung diseases from lung cancer

J Ren, D Zhang, Y Liu, R Zhang, H Fang, S Guo… - Scientific reports, 2016 - nature.com
In this study, we have employed graphene oxide as a matrix to simultaneously and directly
quantify serum nonesterified and esterified fatty acids (FAs) using matrix-assisted …

Detection and verification of coexisting diagnostic markers in plasma and serum of patients with non-small-cell lung cancer

M Yu, R Sun, Y Zhao, F Shao, W Zhu, J Aa - Future Oncology, 2021 - Taylor & Francis
Aim: To screen and identify the potential biomarkers co-existing in plasma and serum of
patients with non-small-cell lung cancer (NSCLC), and establish appropriate diagnostic …