Proteins are multifunctional large organic compounds that constitute an essential
component of a living system. Hence, control over their bioconjugation impacts science at …

Click chemistry has become one of the most powerful construction tools in the field of
organic chemistry, materials science, and polymer science, as it offers hassle-free platforms …

Chemical modification of proteins provides powerful tools to realize a broad range of
exciting biological applications, including the development of new classes of …

Selective modification of native proteins in live cells is one of the central challenges in recent
chemical biology. As a unique bioorthogonal approach, ligand-directed chemistry recently …

Protein analysis under biological conditions is now regarded as indispensable for
understanding the structure and function of proteins, in addition to in vitro studies using …

The Click reaction that involves Cu (I)-catalyzed azide–alkyne cycloaddition (CuAAC) serves
as the most potent and highly dependable tool for the development of many complex …

Background: The tissue engineering and regenerative medicine approach require
biomaterials which are biocompatible, easily reproducible in less time, biodegradable and …

The covalent inhibition of a target protein has gained widespread attention in the field of
drug discovery. Most of the current covalent drugs utilize the high reactivity of cysteines …

Targeted covalent inhibitors are an important class of drugs and chemical probes. However,
relatively few electrophiles meet the criteria for successful covalent inhibitor design. Here we …

Chemical modification of proteins is important for creating a myriad of engineered proteins
and for elucidating the function and dynamics of proteins in live cells. A wide variety of …