Abstract Pyridoxal-5′-phosphate (vitamin B 6) binding enzymes form a large superfamily
that contains at least five different folds. The availability of an increasing number of known …

Actinosynnema pretiosum. Many of these compounds are antitumor agents of extraordinary
potency, yet phase II clinical trials with maytansine proved disappointing. The chemistry and …

Covering: up to early 2001The biosynthesis and mode of attachment of a wide range of
polyketide synthase (PKS) starter units in bacteria are covered in this review. Natural …

The mitomycins (Figure 1) are a unique family of natural products with a rich history. Hata
and co-workers at Kwoya Hakko Kogyo Co. in Japan first isolated mitomycins A and B from …

The genomics revolution has unveiled a wealth of poorly characterized proteins. Scientists
are often able to produce milligram quantities of proteins for which function is unknown or …

Covering: 1957 to 2011 3-Amino-5-hydroxy benzoic acid (3, 5-AHBA) is a precursor for a
large group of natural products, including the family of naphthalenic and benzenic …

In Escherichia coli and Salmonella typhimurium, addition of the 4-amino-4-deoxy-l-
arabinose (l-Ara4N) moiety to the phosphate group (s) of lipid A is required for resistance to …

The aminoshikimate pathway of formation of 3-amino-5-hydroxybenzoic acid (AHBA), the
precursor of ansamycin and other antibiotics is reviewed. In this biosynthesis, genes for …

This is the second part (Part B) of a review that summarises the literature for Type I
polyketide biosynthesis in bacteria from the end of 1994 through to mid-2000, and should be …

Serine hydroxymethyltransferase (SHMT) is a member of the fold type I family of vitamin B6‐
dependent enzymes, a group of evolutionarily related proteins that share the same overall …