Tumors are one of the main causes of death in humans. The development of safe and
effective methods for early diagnosis and treatment of tumors is a difficult problem that needs …

Mesenchymal stem or stromal cells (MSCs) are pluripotent cells implicated in a broad range
of physiological events, including organogenesis and maintenance of tissue homeostasis as …

Background Ferroptosis is a novel mode of non-apoptotic cell death induced by build-up of
toxic lipid peroxides (lipid-ROS) in an iron dependent manner. Cancer-associated …

Innate immune defense against deep tissue infection by Staphylococcus aureus is
orchestrated by fibroblasts that become antimicrobial when triggered to differentiate into …

How basal cell carcinoma (BCC) interacts with its tumor microenvironment to promote
growth is unclear. We use singe-cell RNA sequencing to define the human BCC ecosystem …

BACKGROUND Metastases are the hallmark of lethal cancer, though underlying
mechanisms that drive metastatic spread to specific organs remain poorly understood …

Heart failure is accompanied by adverse cardiac remodeling involving extracellular matrix
(ECM). Cardiac ECM acts as a major reservoir for many proteins including growth factors …

Mesenchymal/stromal stem cells (MSCs) are a crucial component of the tumour
microenvironment (TME). They can be recruited from normal tissues into the TME and …

Objectives This study aimed to investigate the role and mechanism of asporin in modulating
chondrocyte senescence in OA pathology. Methods Asporin and senescence-related …

Cribriform prostate cancer, found in both invasive cribriform carcinoma (ICC) and intraductal
carcinoma (IDC), is an aggressive histological subtype that is associated with progression to …