Abstract The synthesis of 1, 2-dihydroisoquinoline,[2, 1-a] isoquinoline and [5, 1-a]
isoquinoline is very important because of their biological and medicinal activities as well as …

Retrometabolic drug design (RMDD) approaches are systematic methodologies aimed to
design safe compounds with an improved therapeutic index. RMDDs thoroughly integrate …

Abstract Novel rhodium‐catalyzed [3+ 3] annulations of diazoenals and α‐amino ketones
has been disclosed here. The reactivity of diazoenals has been switched from carbenoid to …

Innovative approach to drug design that's more likely to result in an approvable drug product
Retrometabolic drug design incorporates two distinct drug design approaches to obtain soft …

A two steps sequence of silylcarbocyclisation‐TBAF promoted desilylation/aryl migration has
been applied to the synthesis of indolines and tetrahydroisoquinolines derivatives starting …

Polymeric drugs carrying glycolipids have been designed as target macromolecules for the
treatment of brain tumours. A methacrylate derivative of oleyl 2-acetamido-2-deoxy-α-d …

1, 2-Dihydroisoquinolines are important compounds due to their biological and medicinal
activities, and numerous approaches to their synthesis have been reported. Recently, we …

A novel pseudo-four-component condensation yielding 1-aminoimidazo [5, 1-a]
isoquinolinium salts from isocyanides, isoquinoline, and sulfonic or bromic acids is …

The enantiomeric enrichment of racemic 1-benzylated Reissert compounds under
organocatalytic biphasic conditions is presented. The enrichment is the consequence of an …

A series of novel blue-light-emitting 2H-imidazo [5, 1-a] isoquinolinium chloride derivatives
were synthesized by the reaction of isoquinoline with trifluoroacetimidoyl chlorides and …