Background & aims The CEL gene encodes the digestive enzyme carboxyl ester lipase.
CEL-HYB1, a hybrid allele of CEL and its adjacent pseudogene CELP, is a genetic variant …

Cellular stresses elicit signaling cascades that are capable of either mitigating the inciting
dysfunction or initiating cell death. During endoplasmic reticulum (ER) stress, the …

Objective Increasing evidence implicates mutation-induced protein misfolding and
endoplasm reticulum (ER) stress in the pathophysiology of chronic pancreatitis (CP). The …

Inborn mutations in the digestive protease carboxypeptidase A1 (CPA1) gene may be
associated with hereditary and idiopathic chronic pancreatitis (CP). Pathogenic mutations …

Acute pancreatitis (AP) is a common and potentially lethal disease. Over the last 10 years,
AP has become one of the most important healthcare problems. On a global scale, the …

ABSTRACT Background/Objectives Genetic variants in PRSS1 encoding human cationic
trypsinogen are associated with hereditary pancreatitis. The clinically frequent variants exert …

目的: 基于转录组学探索调脾承气汤改善高热量和高蛋白食物导致积食小鼠的分子机制. 方法:
C57 小鼠被随机分为正常对照组, 模型组, 调脾承气汤低剂量组(145 mg/mL) …

The aim of the study was to define the spectrum of genetic risk factors of chronic pancreatitis
(CP) development in patients living in the European part of the Russian Federation …

AIM: To explore the molecular mechanism of Tiaopi Chengqi decoction (TpCqD) improving
hyperthermia and high-protein food-induced hyperphagia mice based on transcriptomics …

Simple Summary This report shows that KLF5 plays a crucial role in the progression of
chronic pancreatitis to pre-neoplastic precursor lesions. Notably, the deletion of Klf5 from …