Advances in covalent kinase inhibitors
A Abdeldayem, YS Raouf, SN Constantinescu… - Chemical Society …, 2020 - pubs.rsc.org
Over the past decade, covalent kinase inhibitors (CKI) have seen a resurgence in drug
discovery. Covalency affords a unique set of advantages as well as challenges relative to …
discovery. Covalency affords a unique set of advantages as well as challenges relative to …
N-terminal proteoforms in human disease
A Bogaert, E Fernandez, K Gevaert - Trends in biochemical sciences, 2020 - cell.com
The collection of chemically different protein variants, or proteoforms, by far exceeds the
number of protein-coding genes in the human genome. Major contributors are alternative …
number of protein-coding genes in the human genome. Major contributors are alternative …
Expression-based, consistent biomarkers for prognosis and diagnosis in lung cancer
M Arroyo, R Larrosa, J Gómez-Maldonado… - Clinical and …, 2020 - Springer
Overview Lung cancer is one of the deadliest cancers in the world. Its histological
classification depends on early diagnosis and successful treatment. Therefore, having …
classification depends on early diagnosis and successful treatment. Therefore, having …
Discovery of (R)-5-(benzo [d][1, 3] dioxol-5-yl)-7-((1-(vinylsulfonyl) pyrrolidin-2-yl) methyl)-7H-pyrrolo [2, 3-d] pyrimidin-4-amine (B6) as a potent Bmx inhibitor for the …
L He, D Li, C Zhang, P Bai, L Chen - Bioorganic & medicinal chemistry …, 2017 - Elsevier
Described as a Btk inhibitor, ibrutinib also potently inhibits Bmx and EGFR, two good targets
for lung cancer. Owing to its high CLogP (4.07) and low aqueous solubility (< 0.01 mg/ml) …
for lung cancer. Owing to its high CLogP (4.07) and low aqueous solubility (< 0.01 mg/ml) …
Serum profiling identifies ibrutinib as a treatment option for young adults with B‐cell acute lymphoblastic leukaemia
S Jordaens, L Cooksey, S Bonney… - British Journal of …, 2020 - Wiley Online Library
Acute lymphoblastic leukaemia (ALL) is a haematological malignancy that is characterized
by the uncontrolled proliferation of immature lymphocytes. 80% of cases occur in children …
by the uncontrolled proliferation of immature lymphocytes. 80% of cases occur in children …
骨髓激酶X 对宫颈癌细胞增殖的影响及可能的作用机制
李晓兰， 赵骏达， 马俊旗 - 中国癌症防治杂志, 2019 - zgazfz.com
目的探讨骨髓激酶X (bone marrow X-linked kinase, BMX) 对人宫颈癌细胞增殖的影响及其
可能的作用. 方法收集2013—2017 年本院34 例正常宫颈, 25 例原位宫颈癌和52 …
可能的作用. 方法收集2013—2017 年本院34 例正常宫颈, 25 例原位宫颈癌和52 …
[PDF][PDF] Roles of alternative splicing in the pathogenesis of lung cancer
H Liu, L Li, X Zhang, D Cui - Cancer Cell and Microenvironment, 2017 - scholar.archive.org
Alternative splicing contributes to the vast complexity of mRNA transcripts and protein
isoforms. It has been estimated that the majority of protein-coding genes are subject to …
isoforms. It has been estimated that the majority of protein-coding genes are subject to …