Mycobacterium tuberculosis, the bacterium responsible for tuberculosis, is one of the most
successful pathogens in human history. An extremely resilient cell wall and highly evolved …

Stimulator of interferon genes (STING) is a receptor in human cells that senses foreign cyclic
dinucleotides that are released during bacterial infection and in endogenous cyclic GMP …

The biology of mycobacteria is dominated by a complex cell envelope of unique composition
and structure and of exceptionally low permeability. This cell envelope is the basis of many …

Many bacterial species use Type VI secretion systems (T6SSs) to deliver anti-bacterial
effector proteins into neighbouring bacterial cells, representing an important mechanism of …

Axon degeneration is a central pathological feature of many neurodegenerative diseases.
Sterile alpha and Toll/interleukin-1 receptor motif-containing 1 (SARM1) is a nicotinamide …

Mycobacterium tuberculosis (Mtb) disrupts glycolytic flux in infected myeloid cells through an
unclear mechanism. Flux through the glycolytic pathway in myeloid cells is inextricably …

Brucella species are facultative intracellular Gram-negative bacteria relevant to animal and
human health. Their ability to establish an intracellular niche and subvert host cell pathways …

Mycobacterium tuberculosis secretes the tuberculosis necrotizing toxin (TNT) to kill host
cells. Here, we show that the WXG100 proteins EsxE and EsxF are essential for TNT …

Mycobacterium tuberculosis is the cause of tuberculosis (TB), a disease which continues to
overwhelm health systems in endemic regions despite the existence of effective combination …

The mechanisms whereby Mycobacterium tuberculosis (Mtb) rewires the host metabolism in
vivo are surprisingly unexplored. Here, we used three high-resolution mass spectrometry …