The loss of germ cells and spermatogenic failure in non-obstructive azoospermia are
believed to be the main causes of male infertility. Laboratory studies have used in vitro …

Traditional therapeutic interventions aim to restore male fertile potential or preserve sperm
viability in severe cases, such as semen cryopreservation, testicular tissue, germ cell …

Application of a three-dimensional (3D) culture system for in vitro proliferation and
differentiation of human spermatogonial stem cells (SSCs) is a useful tool for the …

Tissue engineering has facilitated the development of novel therapeutic strategies for male
reproductive disorders. Decellularized extracellular matrix (ECM) scaffolds provide a wide …

Purpose Successful in vitro transplantation of spermatogonial stem cells (SSCs) demands
effective culture systems for SSCs proliferation and differentiation. Natural extracellular …

Male germline stem cells (mGSCs), also known as spermatogonial stem cells (SSCs), are
the fundamental seed cells of male animal reproductive physiology. However …

Sperm, a crucial gamete for reproduction in sexual reproduction, is generated through the
proliferation, differentiation, and morphological transformations of spermatogonial stem cells …

Male infertility is among one of the most challenging health concerns in the world.
Traditional therapeutic interventions such as semen and testicular tissue cryopreservation …

Purpose This study examined SSC proliferation on an epididymosome-enriched
decellularized testicular matrix (DTM) hydrogel and spermatogenesis induction in …

Testicular tissue engineering for in vitro spermatogenesis aims to restore fertility, focusing on
challenges like efficiency, ethical concerns, and the need for a deeper biological …