Psychiatric genetics has made substantial progress in the last decade, providing new
insights into the genetic etiology of psychiatric disorders, and paving the way for precision …

A polygenic risk score (PRS) is derived from a genome-wide association study and
represents an aggregate of thousands of single-nucleotide polymorphisms that provide a …

We report a multi-ancestry genome-wide association study on liver cirrhosis and its
associated endophenotypes, alanine aminotransferase (ALT) and γ-glutamyl transferase …

Direct-to-consumer (DTC) genetic tests have generated considerable scholarly attention and
public intrigue. Although the current consumer genetic testing regime relies on the reporting …

Summary Background Obstructive Sleep Apnoea (OSA) often co-occurs with
cardiometabolic and pulmonary diseases. This study is to apply genetic analysis methods to …

Polygenic scores (PGS) enable the prediction of genetic predisposition for a wide range of
traits and diseases by calculating the weighted sum of allele dosages for genetic variants …

We assess performance and limitations of polygenic risk scores (PRSs) for multiple blood
pressure (BP) phenotypes in diverse population groups. We compare “clumping-and …

Abstract Background The Toronto Adolescent and Youth (TAY) Cohort Study will
characterize the neurobiological trajectories of psychosis spectrum symptoms, functioning …

Although previous polygenic risk score (PRS) studies for cardiovascular disease (CVD)
focused on incidence, few studies addressed CVD mortality and quantified risks by …

No study, to our knowledge, has constructed a polygenic risk score based on clinical blood
pressure and investigated the association of genetic and lifestyle risks with home …