Tetrahydroisoquinoline derived PRMT5-inhibitors
YE Bergman, RC Foitzik, BJ Morrow… - US Patent …, 2019 - Google Patents
2017-03-01 Assigned to CTXT PTY. LTD. reassignment CTXT PTY. LTD. ASSIGNMENT OF
ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: BERGMAN, YLVA …
ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: BERGMAN, YLVA …
Aminoindane-, aminotetrahydronaphthalene-and aminobenzocyclobutane-derived PRMT5-inhibitors
YE Bergman, R Lessene, D Ganame… - US Patent …, 2018 - Google Patents
2017-03-01 Assigned to CTXT PTY. LTD. reassignment CTXT PTY. LTD. ASSIGNMENT OF
ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: BERGMAN, YLVA …
ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: BERGMAN, YLVA …
Tetrahydroisoquinoline derived PRMT5-inhibitors
RC Foitzik, MA Camerino, SR Walker… - US Patent …, 2020 - Google Patents
US10647708B2 - Tetrahydroisoquinoline derived PRMT5-inhibitors - Google Patents
US10647708B2 - Tetrahydroisoquinoline derived PRMT5-inhibitors - Google Patents …
US10647708B2 - Tetrahydroisoquinoline derived PRMT5-inhibitors - Google Patents …
Tetrahydroisoquinolines as PRMT5 inhibitors
YE Bergman, MA Camerino, SR Walker… - US Patent …, 2019 - Google Patents
ABSTRACT A compound of formula (I) wherein: n is 1 or 2; p is 0 or 1; Ria, Rib, Rlc and Rld
are independently selected from the group consisting of H, halo, Cl-4 alkoxy, C1-4 alkyl, C1 …
are independently selected from the group consisting of H, halo, Cl-4 alkoxy, C1-4 alkyl, C1 …
Pyridine derivatives and their use in the treatment of cancer and hemoglobinopathies
PA Stupple - US Patent 10,745,380, 2020 - Google Patents
Primary Examiner—Zinna Northington Davis (74) Attorney, Agent, or Firm Stites & Harbison
PLLC; Richard S. Myers, Jr.(57) ABSTRACT A compound of formula (la),(b) or (Ic) wherein: n …
PLLC; Richard S. Myers, Jr.(57) ABSTRACT A compound of formula (la),(b) or (Ic) wherein: n …
Benzopiperdine derivatives and their use in the treatment of cancer and hemoglobinopathies
YE Bergman, MA Camerino, PA Stupple - US Patent 10,787,434, 2020 - Google Patents
(57) ABSTRACT A compound of formula I:(I) wherein: n is 1 or 2; p is 0 or 1; Ria, R1b, Rlc
and Rid are independently selected from H, halo, C1-4 alkyl, C1-4 fluoroalkyl, C3-4 …
and Rid are independently selected from H, halo, C1-4 alkyl, C1-4 fluoroalkyl, C3-4 …
3-oxa-8-azabicyclo [3.2. 1] octane derivatives and their use in the treatment of cancer and hemoglobinopathies
PA Stupple - US Patent 10,519,167, 2019 - Google Patents
(57) ABSTRACT A compound of formula Ia, Ib, Ic or Id: wherein: n is 1 or 2; R" is Hor Me; R'is
optionally one or more halo or methyl groups; R" and R" are independently selected from the …
optionally one or more halo or methyl groups; R" and R" are independently selected from the …
Aluminum, [μ‐(1,4‐Diazabicyclo[2.2.2]octane‐κN1:κN4)]hexamethyldi
S Woodward - Encyclopedia of Reagents for Organic Synthesis, 2001 - Wiley Online Library
Abstract InChI= 1S/C6H12N2. 6CH3. 2Al/c1‐2‐8‐5‐3‐7 (1) 4‐6‐8;;;;;;;;/h1‐6H2; 6* 1H3;;
InChIKey= WSTAITCRSVOCTK‐UHFFFAOYSA‐N (reagent used as a source of one‐carbon …
InChIKey= WSTAITCRSVOCTK‐UHFFFAOYSA‐N (reagent used as a source of one‐carbon …
3-oxa-8-azabicyclo [3.2. 1] octane derivatives and their use in the treatment of cancer and hemoglobinopathies
PA Stupple - US Patent 11,028,101, 2021 - Google Patents
US11028101B2 - 3-oxa-8-azabicyclo[3.2.1]octane derivatives and their use in the treatment of
cancer and hemoglobinopathies - Google Patents US11028101B2 - 3-oxa-8-azabicyclo[3.2.1]octane …
cancer and hemoglobinopathies - Google Patents US11028101B2 - 3-oxa-8-azabicyclo[3.2.1]octane …
PRMT5 inhibitors
PA Stupple, SR Walker, MA Camerino - US Patent 10,961,256, 2021 - Google Patents
A compound of formula (la),(b) or (Ic) wherein: n is 1 or 2; R^ is H or Me; R'is optionally one
or more halo or methyl groups; R24 and R26 are independently selected from the group …
or more halo or methyl groups; R24 and R26 are independently selected from the group …