Antisense oligonucleotides (ASOs) are an important tool for the treatment of many genetic
disorders. However, similar to other gene drugs, vectors are often required to protect them …

Immune‐mediated inflammatory diseases (IMIDs) impose an immeasurable burden on
individuals and society. While the conventional use of immunosuppressants and disease …

Antisense oligonucleotides (ASOs) are short, single-stranded nucleic acid molecules that
alter gene expression. However, their transport into appropriate cellular compartments is a …

Phosphorothioate (PS)-modified antisense oligonucleotide (ASO) drugs enter cells through
endocytic pathways where a majority are entrapped within membrane-bound endosomes …

Therapeutic nucleic acids (TNAs) including antisense oligonucleotides (ASOs) and small
interfering RNA (siRNA) have emerged as promising treatment strategies for a wide variety …

Antisense oligonucleotides (ASOs) have emerged as a promising therapeutic approach for a
wide variety of diseases, offering the potential to modulate gene expression with a high …

The selective permeability of the plasma membrane controls cellular uptake of all entities.
Biomolecules are unable to passively diffuse across the cell membrane due to their large …

Antisense oligonucleotides (ASOs) represent a powerful therapeutic modality that can
selectively modulate gene expression. However, ASOs face two major hurdles that restrict …