A common null polymorphism (rs1815739; R577X) in the gene that codes for α-actinin-3
(ACTN3) has been related to different aspects of exercise performance. Individuals who are …

The age-related decline in skeletal muscle mass, strength and function known as
'sarcopenia'is associated with multiple adverse health outcomes, including cardiovascular …

Purpose The present study aimed to investigate the potential impact of age, gender,
baseline strength, and selected candidate polymorphisms on maximal strength training …

Topoisomerase IB (Top1) is a key eukaryotic nuclear enzyme that regulates the topology of
DNA during replication and gene transcription. Anticancer drugs that block Top1 are either …

Homozygosity for a premature stop codon (X) in the ACTN3 “sprinter” gene is common in
humans despite the fact that it reduces muscle size, strength and power. Because of the …

The purpose of this study is to analyze the effect of two genetic polymorphisms, ACTN3
R577X, and ACE I/D, on physical condition in a sample of active older women after a two …

Maintaining muscle mass and function is important throughout the lifestyle. While
environmental factors such as physical activity and healthy nutrition are well investigated …

Emerging evidence suggests that the basis for variation in late-life mobility is attributable, in
part, to genetic factors, which may become increasingly important with age. Our objective …

Background The ACTN3 gene is primarily expressed in fast skeletal muscle fibres. A
common nonsense polymorphism in this gene is ACTN3 R577X (rs1815739), which causes …

Genome variations contribute to the vast majority of interindividual differences and may
decisively influence sports capability. This study was conceived as a means of finding out …